When rabbits were injected with 10.0 mg rabbit thyroglobulin in complete Freund's adjuvant, the earliest thyroid lesions were seen on day 5 and uniformly severe thyroid lesions were seen by day 14; these observations were not significantly different from the thyroid lesions observed at 1 and 2 months post-immunization. Pooled sera were obtained from immunized, thyroidectomized, and nonthyroidec...

Thyroglobulin (Tg) is a large glycoprotein of mol.wt. 660000 synthesized in the thyroid. It is the vehicle for the unique route of biological synthesis of thyroxine and contains up to six thyroxyl residues in peptide linkage within its peptide chain. Despite the fact that small quantities are present in the human circulation from birth onwards auto-antibodies to thyroglobulin are commonly found...

Thyroglobulin (Tg) is a precursor for thyroid hormone, specifically synthesized by follicular cells upon stimulation the stimulating hormone (TSH). Damage to caused benign or malignant diseases cause release of Tg into circulation. Differentiated cancer (DTC) most common endocrine malignancy, which has an excellent prognosis if detected and treated early. This review describes clinical laborato...

When CD4+ CD25+ regulatory T cells are depleted or inactivated for the purpose of enhancing antitumor immunity, the risk of autoimmune disease may be significantly elevated because these regulatory T cells control both antitumor immunity and autoimmunity. To evaluate the relative benefit and risk of modulating CD4+ CD25+ regulatory T cells, we established a new test system to measure simultaneo...

background: premature ovarian failure (pof) is a disorder of multi causal etiology. autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in pof. the aim of this study was to identify the level of auto-antibodies in pof and familial pof patients. materials and methods: in this study, auto-antibodies including anti-ovarian antibody (aoa), a...

Thyroglobulin is the precursor of the thyroid hormones, triiodothyronine and thyroxine. Because the molecular size of thyroglobulin is relatively large (660 kDa), it could have other additional functions besides serving as the precursor of the thyroid hormones. In this report, we examined the proliferative effects of thyroglobulins purified from bovine and porcine thyroid tissues on the growth ...