Phenols began to play a prominent role very early in modern operative medicine in the 1860s when Lister introduced his ‘antisepsis’ approach. The treatment of open wounds by carbolic acid dramatically reduced morbidity and mortality of surgical patients for the first time [1]. This central place in operative medicine was lost when, in the early 20th Century, ‘asepsis’ replaced ‘antisepsis’. The...

Phenols began to play a prominent role very early in modern operative medicine in the 1860s when Lister introduced his ‘antisepsis’ approach. The treatment of open wounds by carbolic acid dramatically reduced morbidity and mortality of surgical patients for the first time [1]. This central place in operative medicine was lost when, in the early 20th Century, ‘asepsis’ replaced ‘antisepsis’. The...

Melampodium divaricatum is a medicinal plant, which occurs in Central America. In a recent paper we reported the occurrence of acylated 2-hydroxy thymol glycosides as main constituents in this plant. This paper deals with the isolation of two new 2,5-dihydroxythymol ester derivatives. The formerly reported sesquiterpene lactone mikanokryptin was not found in our plant material.

Two new thymol derivatives, 7,9-diisobutyryloxy-8-ethoxythymol (1) and 7-acetoxy-8-methoxy-9-isobutyryloxythymol (2), were isolated from fresh roots of Ageratina adenophora, together with four known compounds, 7,9-di-isobutyryloxy-8-methoxythymol (3), 9-oxoageraphorone (4), (-)-isochaminic acid (5) and (1α,6α)-10-hydroxycar-3-ene-2-one (6). Their structures were established on the basis of deta...

The development of novel nanomaterials that provide an efficient encapsulation and protection for the active food additives is one of the main focuses of current research efforts at food application areas. From this point of view, in this study, nanofibrous webs from inclusion complexes (IC) of modified cyclodextrins (hydroxypropyl-β-cyclodextrin (HPβCD), hydroxypropyl-γ-cyclodextrin (HPγCD) an...

Thymol is a natural essential oil present in many plants and has many different effects in various cell types. However, the effect of thymol on the physiology of MDCK renal tubular cells is unknown. The action of the phytochemical thymol on cytosolic Ca²⁺ concentrations ([Ca²⁺]i) and apoptosis in Madin-Darby canine kidney (MDCK) renal tubular cells was explored. Fura-2, a Ca²⁺-sensitive fluores...