In the residential area of the North Coast of the Persian Gulf, consumption of fish is a possible source of exposure to heavy metals and other pollutants, all of which may act as potential risk factors for serious syndromes and fatal diseases. Health risks associated with Pb, Cd, and Hg were assessed based on the target hazard quotients (THQ), which can be derived from concentrations of heavy m...

BACKGROUND Considerable research has been directed towards the roles of metal ions in nutrition with metal ion toxicity attracting particular attention. The aim of this study is to measure the levels of metal ions found in selected beverages (red wine, stout and apple juice) and to determine their potential detrimental effects via calculation of the Target Hazard Quotients (THQ) for 250 mL dail...

Abstract One method of probing new physics beyond the Standard Model is to check correlation among higher-dimensional operators in effective field theory. We examine strong between processes and tq , which both depend on same three operators. The indicates that, according data \sigma_{tHq} = \big[106.8 \pm 64.8\big]\; {\rm fb} significantly below current upper li...

A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A tetrahydroquinoline (THQ) scaffold was prepared via an asymmetric Povarov reaction using cooperative catalysis to generate three contiguous stereogenic centers. A matrix of 4 stereoisomers of the THQ scaffold was prepared to enable the develo...

Substituted tetrahydroquinolines (THQs) have been previously identified as inhibitors of mammalian protein farnesyltransferase (PFT). Previously we showed that blocking PFT in the malaria parasite led to cell death and that THQ-based inhibitors are the most potent among several structural classes of PFT inhibitors (PFTIs). We have prepared 266 THQ-based PFTIs and discovered several compounds th...

introduction: tinnitus is a common otologic symptom that can seriously affect a patient’s quality of life. the purpose of the present study was to translate and validate the iowa tinnitus handicap questionnaire (thq) into the persian language, and to make it applicable as a tool for determining the effects of tinnitus on a patient’s life.   materials and methods: the main version of the thq was...

Purpose: The aim of this study was to evaluate histologically and immunohistochemically the cytoprotective effects thymoquinone (THQ) against isoproterenol (ISO)-induced aortic tissue damage.
 Materials Methods: Rats were divided into four groups (n=8). Control group (Control); untreated rats, Thymoquinone (THQ); 20 mg / kg intragastrically (ig) THQ at 24 hour intervals for 8 days, Isoprot...

The post-translational farnesylation of proteins serves to anchor a subset of intracellular proteins to membranes in eukaryotic organisms and also promotes protein-protein interactions. Inhibition of protein farnesyltransferase (PFT) is lethal to the pathogenic protozoa Plasmodium falciparum. Parasites were isolated that were resistant to BMS-388891, a tetrahydroquinoline (THQ) PFT inhibitor. R...

Pollutant concentrations detected in oysters from 12 different culture areas of Taiwan (especially for the Hsiangshan area and the Machu Islands) from 1991-98 were evaluated to investigate potential carcinogenic (inorganic As and organochlorine pesticides) and non-carcinogenic (Cu, Zn, Cd and inorganic As) risk to the public from ingestion of the oysters. The highest geometric mean (GM) Cu and ...

Introduction: Tinnitus is a common otologic symptom that can seriously affect a patient’s quality of life. The purpose of the present study was to translate and validate the Iowa Tinnitus Handicap Questionnaire (THQ) into the Persian language, and to make it applicable as a tool for determining the effects of tinnitus on a patient’s life.   Materials and Methods: The main version of the THQ was...