The present work highlights the synthesis and effect of introducing substituents on nitrogen at position -1 five 2-benzylthiopyrimidine derivatives (6a-e). compounds (6a-e) were obtained by condensation 2-thiopyrimidines (4) with benzyl halides in presence a base. As for N-alkylated/arylated-2thiobenzylpyrimidines (8a-k), they nucleophilic substitution reaction basic medium. All synthesized cha...

A series of selenium analogs of physiologically active thiopurines and thiopyrimidines has recent ly been prepared (9). The well established antitumor activity of some of the analogous mercapto compounds, particularly 6-mercaptopurine, which has enjoyed wide clinical use in the treatment of various types of leukemia (3,12), indicated the desirability of comparing the chemical and biologi cal pr...

5-Alkyl-6-(substituted benzyl)-2-thiouracils 3a,c were reacted with (2-chloroethyl) diethylamine hydrochloride to afford the corresponding 2-(2-diethylamino)ethylthiopyrimidin- 4(3H)-ones 4a,b. Reaction of 3a-c with N-(2-chloroethyl)pyrrolidine hydrochloride and/or N-(2-chloroethyl)piperidine hydrochloride gave the corresponding 2-[2-(pyrrolidin-1-yl)ethyl]-thiopyrimidin-4(3H)-ones 5a-c and 2-[...

Photochemotherapy, the combination of a photosensitiser and ultraviolet (UV) or visible light, is an effective treatment for skin conditions including cancer. The high mutagenicity and non-selectivity of photochemotherapy regimes warrants the development of alternative approaches. We demonstrate that the thiopyrimidine nucleosides 5-bromo-4-thiodeoxyuridine (SBrdU) and 5-iodo-4-thiodeoxyuridine...

Nine new platelet activating factor (PAF) antagonists from 4 different chemical classes (thiopyrimidines: SDZ 59-015; thioimidazolines: SDZ 61-813; imidazoisoquinolines: SDZ 62-434, SDZ 62-759, SDZ 63-135, SDZ 63-596; and imidazopiperidines: SDZ 61-638, SDZ 62-293, SDZ 62-694) have been tested for cytostatic/antiproliferative ([3H]thymidine uptake) and cytotoxic (trypan blue dye exclusion) acti...

The role of tRNA' in accepting and transferring amino acids during protein synthesis has been well documented.2 However, the specific physicochemical mechanisms involved in these reactions have not been completely elucidated. Peterkofsky3 and Carbon4 have shown that physiological or chemical alteration of tRNA affects its capacity to accept amino acids. Recently, Lipsett5 and Carbon4 observed t...

In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuranchalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. The structuresof title compounds (4a-d), (5a-d) and (6a-d) were established on the basis of analyticaland spectral data. The synthesized compounds were screened for antimicrobial activityand molecular docking studies. Some ...

In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuranchalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. The structuresof title compounds (4a-d), (5a-d) and (6a-d) were established on the basis of analyticaland spectral data. The synthesized compounds were screened for antimicrobial activityand molecular docking studies. Some ...