OBJECTIVES Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is confirmed in numerous studies. Any pharmacological intervention in this period may result in structural, functional or behavioral abnormalities. In this study, sodium thiopental a GABA mimetic drug was admi...

introduction: physicians frequently deal with procedures which require sedation of pediatric patients. laceration repair is one of them. no study has been performed regarding the comparison between induction of sedation with sodium thiopental and ketamine in laceration repair. therefore, the present study was aimed to comparison of induced sedation by rectal sodium thiopental and muscular injec...

Objective(s): Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is confirmed in numerous studies. Any pharmacological intervention in this period may result in structural, functional or behavioral abnormalities. In this study, sodium thiopental a GABA mimetic drug was a...

background: electroconvulsive therapy (ect) is usually given to people with severe depression which has not responded to other forms of treatment such as anti-depressants. ect may be accompanied by potentially significant medical complications including prolonged seizures, prolonged apnea, or cardiac or pulmonary complications. modification of ect with brief anesthesia and muscle relaxants shou...

in a cross section of the patients scheduled for various operations, the plausability of lidocaine as an induction agent is studied and described. the results were dismaying suggesting, henceforth, that as an induction agent, lidocaine altogether fails to accomplish the assignment assigned to this drug.

The paper presents studying sedative activity of the combined tincture motherwort and St. John's wort. wort was obtained by percolation method in a ratio 1:10. Standardization carried out with quality indicators: description, content active ingredients ethanol, relative density, dry residue. According to all indicators, met requirements State Pharmacopoeia Republic Belarus. Specific assessed ba...

INTRODUCTION Physicians frequently deal with procedures which require sedation of pediatric patients. Laceration repair is one of them. No study has been performed regarding the comparison between induction of sedation with sodium thiopental and ketamine in laceration repair. Therefore, the present study was aimed to comparison of induced sedation by rectal sodium thiopental and muscular inject...

A general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. Anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. Alkylation of methyl cyanoacetate which was perfo...

The cardiovascular effects of ketamine hydrochloride and thiopental sodium were studied in 11 dogs. During anesthesia, mean heart rate rose to 185 beats/min with ketamine and 147 beats/min with thiopental. Cardiac output was increased with ketamine but unchanged by thiopental. The maximum first derivative of the left ventricular pressure (dP/dt max) fell by 14% with thiopental but did not chang...