the present study was aimed to develop and validate a high performace liquid chromatography method for determination of thiocolchicoside and dexketoprofen trometamol in combined dosage form. the proposed hplc method utilizes an agilent eclipse c-8 column (5 µm, 250×4.6 mm) at ambient temperature. a 23 full factorial design was performed for optimization of mobile phase for separation of two dru...

Thiocolchicoside is a commonly used muscle relaxant in the treatment of acute painful muscle spasms. It exhibits a selective affinity for the inhibitory gamma-aminobutyric acid and glycinergic receptors, although, the exact mechanism for muscle relaxant property is not known. It has a proconvulsant action and hence should be avoided in patients predisposed to seizures. The recent drug warning f...

Background: Thiocolchicoside and chlorzoxazone are commonly used muscle relaxants for the management of acute musculoskeletal pain. However, there is limited evidence comparing their efficacy safety. Aims Objectives: The aim study was to compare safety thiocolchicoside in patients with Materials Methods: This a randomized, open-label, parallel-group conducted tertiary care hospital. A total 50 ...

Objective: The main objective of the present study was to develop a controlled release formulation proniosomes thiocolchicoside. Methods: formulations were prepared with thiocolchicoside varying Span 60 and cholesterol ratio in range 4.5:1–1:4.5 using sucrose stearate as carrier by slurry method. different proniosomal characterized for micromeritic properties further %Entrapment efficiency, %Dr...