The investigation of the biological activity of thiosemicarbazones had as its origin Domagk's attempt to establish a relationship between the structure and antituberculous activity of a series of sulfathiadiazoles which were prepared by cyclizing the corresponding thiosemicarbazones (4). The end product, the thiadiazoles, proved uninteresting, but the intermediate thiosemicarbazones, which were...

The synthesis, structure, electrochemistry, and biological studies of Co(II), Ni(II), Cu(II), and Zn(II) complexes of thiocarbohydrazone ligand are described. The ligand is synthesized starting from thiocarbohydrazide and isatin. It is evident from the IR data that in all the complexes, only one part of the ligand is coordinated to the metal ion resulting mononuclear complexes. The ligand coord...

Reactive methylene group at C2 position in dimedone plays an important role in the synthesis of a variety of organic ligands. Condensed compounds 3, 5, 7 were synthesized by reaction with dimedone and different aromatic aldehydes. Synthesized condensed compounds 3, 5 and 7 were on reaction with hydroxyl amine hydrochloride to yield oximes ligands 8, 9 and 10 respectively. The synthesized oxime ...