Several years ago considerable interest was aroused by the discovery by van Veen and Hyman (1) of a new naturally occurring sulfur-containing amino acid which they had isolated from the djenkol bean (Pithecolobium lobatum) and named djenkolic acid. They showed that it was probably the cysteine thioacetal of formaldehyde. This structure was confirmed by du Vigneaud and Patterson (2) who synthesi...

Immobilisation of biorecognition elements on transducer surfaces is a key step in the development of biosensors. The immobilisation needs to be fast, cheap and most importantly should not affect the biorecognition activity of the immobilised receptor. A novel protocol for the covalent immobilisation of biomolecules containing primary amines using an inexpensive and simple polymer is presented. ...

This review describes the recent advances in photocatalyzed reactions to form new carbon–sulfur and carbon–selenium bonds. With a total of 136 references, which 81 articles are presented, authors introduce five sections an updated picture state art light-promoted synthesis organochalcogen compounds (from 2019 present). The sulfides by direct sulfenylation C–C π-bonds; sulfones; activation Csp2–...

The inhibition of ABC (ATP binding cassette) transporters is considered a powerful tool to reverse multidrug resistance. Zosuquidar featuring a difluorocyclopropyl-annulated dibenzosuberyl moiety has been found to be an inhibitor of the P-glycoprotein, one of the best-studied multidrug efflux pumps. Twelve 5-oxyisoquinoline derivatives, which are analogues of zosuquidar wherein the dibenzosuber...

The dimannosylatedinositol pseudotrisaccharide phospholipid of the lipoarabinomannan (LAM) component of the mycobacterial cell wall has attracted interest as a therapeutic target because of its uniqueness to mycobacteria, its assembly at an early stage in LAM biosynthesis and the immunological activity of oligosaccharides containing this subunit. Accordingly, analogues of this pseudotrisacchari...