Early wound closure is the ultimate goal of burn care. While excisional therapy is necessary in the treatment of both large, full-thickness and deep, partial skin-thickness burns, the majority of burns are superficial partial skin-thickness injuries requiring a different clinical approach. In superficial wounds, cosmetic and functional restoration in conjunction with relief from pain and preven...

We developed the novel silk fibroin-based bilayered wound dressing for the treatment of partial thickness wounds. And it showed relevant characteristics and accelerated the healing of full-thickness wounds in a rat model. This study is the clinical evaluation of the bilayered wound dressing to confirm its safety and efficacy for the treatment of split-thickness skin donor sites. The safety test...

Background:Honey has been shown to accelerate wound healing, which is especially important in the management of patients with full-thickness wounds of skin in dermatologic surgeries. Objective: To evaluate the effects of honey in accelerating healing of full-thickness skin wounds in mice. Methods: Two groups of male NMRI mice (n=12) were subjected to full-thickness skin wounds under general ane...

Objective(s) The process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. Systemic administration of L-arginine promotes wound healing but its global side effects are undesirable. To confine the action of L-arginine at the site of injury, we tested the effects of local administration of L-arginine on the healing of excisio...

The wound healing effect of two calcium channel blockers, nifedipine and amlodipine was studied in rats using incision and excision wound models. In incision wound, two straight paravertebral skin thickness incision were made and on tenth day skin tensile strength was measured by using continuous water flow technique. In excision wound, circular piece of skin excised in its full thickness and w...

BACKGROUND Full-thickness burn wounds require excision and skin grafting. Multiple surgical procedures are inevitable in managing moderate to severe full-thickness burns. Wound bed preparations prior to surgery are necessary in order to prevent wound infection and promote wound healing. Honey can be used to treat burn wounds. However, not all the honey is the same. This study aims to evaluate t...

objective(s) the process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. systemic administration of l-arginine promotes wound healing but its global side effects are undesirable. to confine the action of l-arginine at the site of injury, we tested the effects of local administration of l-arginine on the healing of excision...

     Nowadays, hydrogels are widely used as wound dressings in biomedical applications. Similar to other types of the moist (wet) wound dressings, it is necessary to have sufficient information about their dehydration kinetics during the pre-usage period (e.g. storage duration) and also the wound healing process. In this work, hydrogel wound dressings based on polyvinyl alcohol were prepared by...

BACKGROUND In the extremities of premature infants, the skin and subcutaneous tissue are very pliable due to immaturity and have a greater degree of skin laxity and mobility. Thus, we can expect wounds to heal rapidly by wound contraction. This study investigates wound healing of full-thickness defects in premature infant extremities. METHODS The study consisted of 13 premature infants who ha...