Leishmaniasis and malaria are serious public health problems in tropical and sub-tropical regions worldwide. Development of drug-resistant strains has disrupted efforts to control the spread of these diseases in the world. The conventional antiparasitic chemotherapy still suffers from side effects and drug resistance. Therefore, the development of novel antimalarial and leishmanicidal drugs rem...

Thiirene, Thioketene, 1,2,3-Thiadiazole, Thio-Wolff Rearrangement Photolysis of argon-matrix isolated 4,5-bis(carbomethoxy)-l,2,3-thiadiazole with A = 254 or 265 nm resulted in the almost quantitative formation of bis(carbomethoxy)thiirene (3g). Photolysis of 3g could only be carried out by long irradiation times at short wavelength A = 210nm and resulted mainly in extensive fragmentation inste...

Thiadiazole and their derivatives have been studied extensively because of their wide range of biological activity. They are found to be effective as antibacterial, antimalarial, antiviral, antiinflammatory, anticancer and antianthelminthic agents. Diverse biological activities, such as antibacterial, anti-inflammatory, and antiviral have been associated with 1,3,4Thiadiazole derivatives. The s...

1,3,4-thiadiazole is one of the most potent heterocyclic containing carbonic anhydrase and antibacterial inhibitor from the natural and synthetic origin. It possessed potent anticonvulsant activity in wide range preclinical in vitro and in vivo models. Recently, various 1,3,4-thiadiazole derivatives have been synthesized and evaluated their anticonvulsant activity. This review is a demonstratio...

The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. The search for antiepileptic compounds...

Nitro-containing heteroaromatic derivatives structurally related to nitroimidazole (Metronidazole) are being extensively evaluated against Helicobacter pylori isolates. On the other hand, 1,3,4-thiadiazole derivatives have also demonstrated promising antibacterial potential. In present study, we evaluated anti-H. pylori activity of novel hybrid molecules bearing nitroaryl and 1,3,4-thiadiazole ...

nitro-containing heteroaromatic derivatives structurally related to nitroimidazole (metronidazole) are being extensively evaluated against helicobacter pylori isolates. on the other hand, 1,3,4-thiadiazole derivatives have also demonstrated promising antibacterial potential. in present study, we evaluated anti-h. pylori activity of novel hybrid molecules bearing nitroaryl and 1,3,4-thiadiazole ...

A new series of thiadiazole-enaminones 4 were synthesized via reactions of 5-acetyl-1,3,4-thiadiazoles 3 with dimethylformamide-dimethylacetal (DMF-DMA). The simple phenyl substituted thiadiazole-enaminone 4f was used as a synthetic precursor for the preparation of a wide variety of new heterocyclic compounds, including the 5-substituted-1,3,4-thiadiazole derivatives 5, 6, 11, 12 and 13, which ...

Abstract: Heterocyclic compounds occupy a central position among those molecule that makes life possible. The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4thiadiazole constitutes constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their c...

A series of 5-substituted-2-phenyl-1, 3, 4-thiadiazole were prepared by the reaction of different substituted benzoylisothiocyanate with 5-amino -2-phenyl -1, 3, 4-thiadiazole. The target molecules were characterized by CHNS analysis, IR, NMR and mass spectra. All these new compounds were screened for antibacterial and antifungal activity. Some of those compounds had promising antimicrobial act...