Angiogenesis or formation of new blood vessels from preexisting vasculature is a key process in some physiological conditions such as wound healing, growth, and action of female reproductive organs. Moreover, disturbance of the mechanisms of physiological angiogenesis has a role in pathogenesis of some diseases in the form of overproliferation of blood vessels such as cancers, psoriasis, arthri...

• 3D-exos promote angiogenesis in vivo. exert their function via activation of HMGB1/AKT signaling pathway. have a superior ability HUVEC proliferation, migration, and tube formation. Angiogenesis is an essential step tissue engineering. MSC exosomes play important role angiogenesis. Functional biomolecules vested by the culture microenvironment can be transferred to recipient cells affects eff...