BACKGROUND Pulmonary function testing (PFT) is an important tool in the diagnosis and management of most respiratory conditions, and appropriate interpretation of test results is a fundamental component of the final report. As part of developing a structured approach to interpretation of PFT results, we wished to characterize primary reasons for referral for testing in a range of PFT laboratori...

Pulmonary function tests (PFT) are a battery of tests that measure lung function and aid in the management of patients with respiratory disease. They are performed using standardized equipment and can be used for diagnosis, prognostication, management and follow-up of patients with pulmonary pathology. Although PFT may not identify the exact pathology, it broadly classifies respiratory disorder...

The small-molecule compound pifithrin-A (PFT-A) has been reported to inhibit p53 function and protect against a variety of genotoxic agents. We show here that PFT-A is unstable in tissue culture medium and is rapidly converted to its condensation product PFT-B. Both compounds showed limited solubility with PFT-A precipitating out of tissue culture medium at concentrations >30 Mmol/L. PFT-A and ...

Centennial-scale climate-ecosystem feedbacks are a major source of predictive uncertainty for land-atmosphere fluxes of energy, carbon, and water. Accurate representations of plant functional type (PFT) distributions through time and space are required for modeling centennial-scale feedbacks within Earth system models (ESMs). We tested the ability of ESMs from the Coupled Model Intercomparison ...

The small-molecule compound pifithrin-alpha (PFT-alpha) has been reported to inhibit p53 function and protect against a variety of genotoxic agents. We show here that PFT-alpha is unstable in tissue culture medium and is rapidly converted to its condensation product PFT-beta. Both compounds showed limited solubility with PFT-alpha precipitating out of tissue culture medium at concentrations >30...

Plexiform fibrohistiocytic tumor (PFT) is a rare, low-grade soft tissue tumor that occurrs primarily in children and young adults. The most common location of PFT is the upper extremity, and there are very few reports of PFT in the neck. We report here on a case of PFT presenting as a painless subcutaneous nodule in the neck of a 46-year-old woman. Histologically, this subcutaneous tumor was co...

RATIONALE AND OBJECTIVES The aim of this study was to compare the performance of various image-based metrics computed from thoracic high-resolution computed tomography (HRCT) with data from pulmonary function testing (PFT) in characterizing interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS Fourteen patients with ILD and 11 with COPD had un...

A total of 60 nulliparous crossbred rabbit females were, a posteriori, divided into 2 experimental groups according to their natural “decision” to conceive or not at day 11 post first parturition (L: solelylactating or LP: lactating-pregnant). This design allowed us to study the evolution of body reserves around first parturition and its influence on the future reproductive success of rabbit fe...

The post-translational farnesylation of proteins serves to anchor a subset of intracellular proteins to membranes in eukaryotic organisms and also promotes protein-protein interactions. Inhibition of protein farnesyltransferase (PFT) is lethal to the pathogenic protozoa Plasmodium falciparum. Parasites were isolated that were resistant to BMS-388891, a tetrahydroquinoline (THQ) PFT inhibitor. R...

Autophagy is an evolutionarily conserved intracellular system that maintains cellular homeostasis by degrading and recycling damaged cellular components. The transcription factor HLH-30/TFEB-mediated autophagy has been reported to regulate tolerance to bacterial infection, but less is known about the bona fide bacterial effector that activates HLH-30 and autophagy. Here, we reveal that bacteria...