background: the manner in which healthcare professionals deliver bad news affects the way it is received, interpreted, understood, and dealt with. despite the fact that clinicians are responsible for breaking bad news, it has been shown that they lack skills necessary to perform this task. objectives: the purpose of this study was to explore iranian mothers’ experiences to receive bad news abou...

If we exclude the assumption of normality in return distributions, the classical risk–reward Sharpe Ratio becomes a questionable tool for ranking risky projects. In line with Sharpe thinking, a general risk–reward ratio suitable to compare skewed returns with respect to a benchmark is introduced. The index includes asymmetrical information on: (1) ‘‘good’’ volatility (above the benchmark) and ‘...

In this paper it will be shown that a common modeling approach based on extrapolation from standard (textbook) models may lead to the unnecessary use of the state-event construct. Although this may be hand-waved as the result of bad modeling practice, the running example discussed herein has been used for quite some time as a benchmark problem for event handling in the literature [F. (the bench...

utrition and cell death are integrated in a single mitochondrial complex, according to Nika Danial, Stanley Korsmeyer (Harvard Medical School, Boston, MA), and colleagues. The complex was discovered after gel filtration of the pro-apoptotic BAD protein, and contains BAD, a phosphatase, kinase, and kinase-anchoring protein directed at BAD, and glucokinase. In cells lacking BAD, the complex falls...

utrition and cell death are integrated in a single mitochondrial complex, according to Nika Danial, Stanley Korsmeyer (Harvard Medical School, Boston, MA), and colleagues. The complex was discovered after gel filtration of the pro-apoptotic BAD protein, and contains BAD, a phosphatase, kinase, and kinase-anchoring protein directed at BAD, and glucokinase. In cells lacking BAD, the complex falls...