Abstract Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) suppressor mothers against decapentaplegic (Smad) receptors in high-grade tumors. Material Method Thirteen patients with a pathological diagnosis glioblastoma multiforme were included study. Pathological preparations eac...

The aim of this study to evaluate the expression Programmed cell death-1 (PD-1), TGF- ß, and IL-10 in placental tissue aborted women correlation with Toxoplasma.gondii (T. gondii) these cytokines each other toxoplasmosis, during an abortion. samples have been processed used for immunohistochemistry PDL-1, IL-10, TGF-β. There was increase TGF-β, infected T.gondii, results showed that residence p...

transforming growth factor betas (tgf?s) are one of the most widespread and versatile cytokines. the three mammalian tgf? isoforms, ?1, ?2, and ?3, and their receptors regulate proliferation of neuronal precursors as well as survival and differentiation in neurons of developing and adult nervous system. functions of tgf?s has a wide spectrum ranging from regulating cell proliferation and differ...

Background: TNF-α is a multifunctional proinflammatory cytokine and TGF-β1 is a secretory protein controlling epithelial proliferation and differentiation. Keratocyst presents an aggressive behavior and a growth mechanism different from that of radicular cyst. Aim: In this line, the present study aimed at evaluating TNF-α and TGF-β1 level and its association with histopath...

Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression. The aim of the pres...

Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate effect of PRDX1 on EMT airway epithelial cells stimulated with lipopolysaccharide (LPS) transforming growth factor-beta (TGF-β1). overexpression significantly increased proliferation migration human bronchial (BEAS-...