Alzheimer's disease (AD) is characterized by extensive neuronal death in distinct brain regions, including the frontal cortex and hippocampus, although the specific mechanisms of neuronal degeneration in AD remain a topic of intense scientific pursuit. One model for cell death in AD postulates that abortive cell cycle events in neurons, including tetraploidy, precede neuronal death, and novel t...

v-Src, an oncogene found in Rous sarcoma virus, is a constitutively active variant of c-Src. Activation of Src is observed frequently in colorectal and breast cancers, and is critical in tumor progression through multiple processes. However, in some experimental conditions, v-Src causes growth suppression and apoptosis. In this review, we highlight recent progress in our understanding of cytoki...

Fluroscent in situ hybridization analysis indicated presence of t(12;21)(p13;q22) translocation and near-tetraploidy in a case who 11-year-old boy and diagnosed with B precursor acute lymphoblastic leukemia (ALL). Although, some studies suggest good prognostic effect of translocation t(12;21) (p13;q22), there were very little data regarding the prognostic effect of Near-tetraploidy. Here we dis...

The induction of tetraploidy by means of cold, heat and multiple heat shock treatments was investigated on male fish from a growth-enhanced transgenic tilapia C118 line, crossed with wild type females. After the development a new multiple heat shock protocol (two heat treatments at 41oC in 60 and 80 min. after fertilization for 5 min. per each), chromosome and X-gal in situ staining assays demo...

The induction of tetraploidy by means of cold, heat and multiple heat shock treatments was investigated on male fish from a growth-enhanced transgenic tilapia C118 line, crossed with wild type females. After the development a new multiple heat shock protocol (two heat treatments at 41oC in 60 and 80 min. after fertilization for 5 min. per each), chromosome and X-gal in situ staining assays demo...

Haematologica vol. 85(4):April 2000 2. Borgström GH, Vuopio P, De la Chapelle A. Polyploidy of the bone marrow. Scand J Haematol 1976; 17:12331. 3. Espinet B, Solè F, Woessner S, Florensa L, Besses C, Sans-Sabrafen J. Two new cases of near-tetraploidy in adult acute myeloid leukemia. Cancer Genet Cytogen 1998; 102:131-4. 4. Lemez P, Michalova K, Zemanova Z, et al. Three cases of near-tetraploid...

This report presents the case of a 15-year-old male with severe chronic neutropenia, leukopenia, and persistent tetraploid mosaicism in the bone marrow and peripheral blood. His father had mild neutropenia and bone marrow tetraploidy. Flow cytometric analysis of DNA content peripheral blood showed tetraploidy in 20% of granulocytes and 15% of monocytes. Sequence analysis of the ELA2 gene was no...

In this study, I attempted to induce tetraploidy in the rainbow trout by means of 28 degrees C-heat shocks applied to fertilized eggs. Variations in the parameters of treatment resulted in large differences in survival rates between the batches, and varying proportions of tetraploid, diplotetraploid and diploid embryos were obtained with shocks beginning between 6 h 30 min and 9 h after fertili...