Bleomycin is used in combination with other antineoplastic agents to effectively treat lymphomas, testicular carcinomas, and squamous cell carcinomas of the cervix, head, and neck. However, resistance to bleomycin remains a persistent limitation in exploiting the full therapeutic benefit of the drug with other types of cancers. Previously, we documented that the Saccharomyces cerevisiae L-carni...

1. The effects of retinol and retinoic acid supplementation of retinol-deficient rats were studied for a variety of metabolic processes shown to be affected by retinol-deficiency. 2. Retinol-deficient rats were found to have decreased body-weight, liver and testes weights, a degeneration of testicular germinal cells, an increased incorporation of labelled choline into liver and testes phospholi...

context to review and summarize the literature regarding the current status of postchemotherapy laparoscopic retroperitoneal lymph node dissection (pcl-rplnd) in patients with testicular germ cell tumor. evidence acquisition a comprehensive review of the english literature was performed using the pubmed database using the terms “laparoscopy” or “laparoscopic”, retroperitoneal lymph node dissect...

Although most animals with scrotal testes are susceptible to cadmium-induced testicular toxicity, strain-related differences are seen in mice. Resistant murine strains demonstrate a decreased cadmium concentration in the testis and also in the epididymis and seminal vesicle. In this study we analyzed cadmium transport into tissues with a vascular barrier, the testis, epididymis, and brain, in a...

background: zinc (zn) as an important trace element is essential for testicular development and spermatogenesis. molecular mechanism of zn action in the reproductive system may be related to metal binding low-molecular weight proteins, metallothioneins (mt). our objective was to determine the effect of zn on two important isoforms of mt, mt1m and mt1g genes expression on testicular sertoli cell...

848 testicular biopsy slides of 664 infertile men were reviewed from the archive of jahad daneshgahi pathology center. tite mean age of patients was 33 years. bilateral testicular biopsies were performed in 197 cases. in 47 cases (23.9%) the histopathologic findings were not identical mixed pattern were encountered frequently which must be kept in mirul in pathologic evaluations and reports.

Background: Zinc (Zn) as an important trace element is essential for testicular development and spermatogenesis. Molecular mechanism of Zn action in the reproductive system may be related to metal binding low-molecular weight proteins, metallothioneins (MT). Our objective was to determine the effect of Zn on two important isoforms of MT, MT1M and MT1G genes expression on testicular sertoli cell...

Testosterone deficiency is commonly associated with obesity, metabolic syndrome, type 2 diabetes and their clinical consequences-hepatic steatosis and atherosclerosis. The testicular feminised mouse (non-functional androgen receptor and low testosterone) develops fatty liver and aortic lipid streaks on a high-fat diet, whereas androgen-replete XY littermate controls do not. Testosterone treatme...