3-Phenylaminoisoxazol-5(2H)-ones,s ubstituted on nitrogen with an isoquinoline or quinazoline group, react with tertiary amine bases to give imidazo annelated compounds. When the N-substituent is a nitropyridine, 2-aminoindole derivatives are formed instead. Evidence is presented that the reactions proceed by initial addition of the tertiary arnine to C-4

3-phenylaminoisoxazol-5(2h)-ones,s ubstituted on nitrogen with an isoquinoline or quinazoline group, react with tertiary amine bases to give imidazo annelated compounds. when the n-substituent is a nitropyridine, 2-aminoindole derivatives are formed instead. evidence is presented that the reactions proceed by initial addition of the tertiary arnine to c-4

background: diabetes is a leading cause of cardiovascular disease (cvd). moreover, cvd accounts for primary cause of death among diabetic patients. physicians, especially in the primary care setting, have effective role in the management of cardiovascular risk factors. therefore, we aimed to compare the prevalence of modifiable cardiovascular risk factors in type 2 diabetic patients attending t...

environmental hazards caused by living conditions and human behaviour in residential areas are types of manmade hazards which have rarely been studied and documented in literature. available studies that had considered theconventional residential environment had proved that residents’ perception were influenced by human and environmental factors. with focus on educational institutions, this pap...

introduction: the study was conducted to assess the school activity of thalassemic children and to reveal the relationship between school activity with the socio-demographic factors as well as clinico-therapeutic profile. methods: a total of 365 admitted thalassemic patients of burdwan medical college (ages 5 to 12 years) were participated in this cross sectional descriptive study conducted on ...

ing in Nebraska. Cornhusker Family Physician 2007; 53:54–5. 10. Miller LG, Diep BA. Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis 2008; 46:752–60. 11. Padoveze MC, de Jesus Pedro R, Blum-Menezes D, Bratfich OJ, Moretti ML. Staphylococcus aureus nasal colonization...

The first Suzuki cross-couplings of unactivated tertiary alkyl electrophiles are described. The method employs a readily accessible catalyst (NiBr(2)·diglyme/4,4'-di-tert-butyl-2,2'-bipyridine, both commercially available) and represents the initial example of the use of a group 10 catalyst to cross-couple unactivated tertiary electrophiles to form C-C bonds. This approach to the synthesis of a...

While tertiary boranes undergo efficient protodeboronation with carboxylic acids, tertiary boronic esters do not. Instead, we have discovered that CsF with 1.1 equiv of H2O (on tertiary diarylalkyl boronic esters) or TBAF·3H2O (on tertiary aryldialkyl boronic esters) effect highly efficient protodeboronation of tertiary boronic esters with essentially complete retention of configuration. Furthe...