Reactivation of antigen induced arthritis by bacterial lipopolysachharide (LPS) in a murine model was used to determine whether Terminalia chebula exerts its protective activity via modulation of Toll-like receptors (TLR). Arthritis was induced in 8-9 weeks old female Swiss albino mice by intra-articular antigen challenge following immunization with antigen. Oral administration of LPS caused re...

To evaluate whether an aqueous seed extract of Terminalia chebula Retzius inhibited development of atopy in vivo, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic symptoms to investigate the effects of the extract. We measured CD4+ cell numbers by hematoxylin and eosin (H&E) staining, and determined the expression levels of matrix metalloproteinase (MMP)-9, interleukin (...

The study evaluated the in vitro iron chelating, lipid peroxidation inhibitory and DNA protective activities of hydroalcoholic (60% ethanolic) extracts of various plant parts of Terminalia chebula, Caesalpinia crista, Cajanus cajan, Terminalia belerica, Emblica officinalis, and Tinospora cordifolia. The iron chelating property of the plants is in accordance with the order of their IC50 values f...

Objective: To study the anti-arthritic activity of Acetone Extract of fruits of Terminalia chebula (TCE) in wistar rats in an experimental model of rheumatoid arthritis. Materials and methods: After necessary approval from Institutional Animal Ethics Committee (IAEC), 28 wistar albino rats of either sex (150-200gm) were randomly divide into 7 groups. Arthritis was induced in all animals by intr...

PURPOSE Kidney stone is one of the most prevalent diseases worldwide. Calcium oxalate (CaOx) has been shown to be the main component of the majority of stones formed in the urinary system of the patients with urolithiasis. The present study evaluates the antilithiatic properties of Terminalia chebula commonly called as ″harad ″ which is often used in ayurveda to treat various urinary diseases i...

the dried fruit of terminalia chebula is widely used for its laxative properties. the objective of the present study was to examine the flowability and compressibility of terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. initial studies on flowability and compressibility revealed that the fruit powder...

Thirty-seven plant organs, traditionally used as drugs, collected in Pakistan, were extracted with 70% acetone and analyzed for their total phenolics concentration and antioxidant potential. Seven extracts showed more than 85% inhibition of lipid peroxidation in vitro as compared with blank. Butylated hydroxytoluene (BHT) (IC50 = 233.6 microg/l +/- 28.3) was the strongest antioxidant in our tes...

The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was P. betel>...

Pharmacognostical studies on the South Indian market sample of Karkatasringi (Terminalia chebula leaf galls) were carried out along with comparative studies on Pistacia integerima which is the accepted source of Karkatasringi. The galls of T. chebula are also known as Kadukkai Poo in Siddha system.

The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts of Terminalia bellerica and T. chebula fruits were evaluated for their analgesic activity using the tail immersion model in mice. The ethanolic extracts of both the plants exhibited analgesic response at 200,400 and 800mg/kg. The studies were further carried for 15 days to evaluate the effect of these extracts in chroni...