It is estimated that 10-15% of couples are infertile and male factors account for about half of these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men have been able to father offspring. However, teratozoospermia still remains a big challenge to tackle. Septins belong to a family of cytoskeletal proteins with GTPase activity and are involved in various biolo...

Abstract Study question Does blastocysts’ iDAScore® differs when ICSI is performed instead of IMSI in case teratozoospermia on the day vitro fertilization (D0)? Summary answer Blastocysts’ unchanged or at (D0). What known already In routine practice, for D0-teratozoospermia sometimes not because its higher cost and/or laboratory workload. Time-Lapse studies have shown that (IVF) using suboptima...

A selection for sperm quality was carried out in the White Plymouth Rock population of the Spelderholt institute. The percentage of morphologically abnormal spermatozoa was used as the most important selection criterion. The population was selected in two directions, viz. a line with a low incidence (Ll-line) of abnormal spermatozoa and a line with a high incidence (Hl-line). Cocks were examine...

Abstract Study question Whether and how METTL5 regulates germ cell development during spermatogenesis. Summary answer is required for spermiogenesis. Loss of resulted in teratozoospermia male infertility via reduced translation acrosome flagellum formation proteins. What known already The roles m6A modifications on mRNA spermatogenesis have been extensively studied. It was reported that knockou...

The protective effect of vitamin E (VE, α-tocopherol) on methyl methanesulfonate (MMS)-induced teratozoospermia was investigated in adult rats. Rats (n=6 per group) were divided into three groups: i) Control group, treated with distilled water from days 1 to 5; ii) the MMS group, treated with MMS at a dose of 40 mg·kg(-1) from days 1‑5; or iii) the VE+MMS group, treated with MMS at a dose of 40...

Teratozoospermia (<40% morphologically normal spermatozoa/ejaculate) is a frequent phenomenon in feline species. This research was carried out to study the possible differences in testicular volume, differential sperm morphometric traits, and potential differences regarding the sperm subpopulational structure during epididymal sperm maturation in teratozoospermic feline donors. Epididymal sperm...

Cis-antisense gene pairs (CASGPs) can transcribe mRNAs from an opposite strand of a given locus. To classify and understand diverse CASGP phenomena in the human we compiled a genome-wide catalog of CASGPs and integrated these sequences with microarray, SAGE and miRNA data. Using the concept of overlapping regions and clustering of SA transcripts by chromosome coordinates, we identified up to 90...