Our experimental findings show that succinate and ascorbate greatly reduce the teratogenic effects of 3-acetylpyridine, 6-aminonicotinamide and sulfanilamide. Glycerophosphate led to similar alleviating results when used in combination with 3-acetylpyridine and 6-aminonicotinamide, but not with sulfanilamide. With certain other teratogens the high-energy intermediates failed to alleviate; in so...

Teratogens are compounds that can induce birth defects upon exposure of the developing fetus. To date, most teratogen studies utilize pregnant rodents to determine compound teratogenicity in vivo. However, this is a low throughput approach that cannot easily meet the need for comprehensive high-volume teratogen assessment, a goal of the US Environmental Protection Agency. In addition, rodent an...

Vitamin A (retinol) is an essential vitamin in the daily functioning of human beings that helps regulate cellular differentiation [2] of epithelial tissue. Studies have shown that an excess of vitamin A can affect embryonic development and result in teratogenesis, or the production of birth defects [3] in a developing embryo. Excess intake of vitamin A and retinoids by pregnant women often resu...

conclusions at present, no single diagnostic procedure is able to cause damage to the embryo or fetus. there are possible harmful effects for doses above 0.2 - 0.25 gy (20-25 rad). context many women of reproductive age and pregnant women require diagnostic tests involving ionizing radiation. fetal exposure to radiation worries both the patient and the obstetricians and could lead to inappropri...

While mice have been used less frequently than rats in behavioral research, there use has some advantages in teratological studies. The development of the mouse CNS has been investigated more extensively than that of the rat. Since time of insult has been found to be an important factor in effects on both anatomy and behavior, data on the sequence of events in CNS development are valuable in pl...

Vitamin A (retinol) is an essential vitamin in the daily functioning of human beings that helps regulate cellular differentiation [2] of epithelial tissue. Studies have shown that an excess of vitamin A can affect embryonic development and result in teratogenesis, or the production of birth defects [3] in a developing embryo. Excess intake of vitamin A and retinoids by pregnant women often resu...

Vitamin A (retinol) is an essential vitamin in the daily functioning of human beings that helps regulate cellular differentiation [2] of epithelial tissue. Studies have shown that an excess of vitamin A can affect embryonic development and result in teratogenesis, or the production of birth defects [3] in a developing embryo. Excess intake of vitamin A and retinoids by pregnant women often resu...