BACKGROUND The promotion of the healing process following musculoskeletal injuries comprises growth factor signalling, migration, proliferation and apoptosis of cells. If these processes could be modulated, the healing of tendon tissue may be markedly enhanced. Here, we report the use of the Somagen™ device, which is certified for medical use according to European laws. It generates low-frequen...

background:the aim of this study is to find out the spatial and temporal expression of tgf-b1 during the tendon healing, after application of platelet rich plasma (prp). methods: a patellar tendon defect model in rabbits was used for this purpose. 48 skeletally mature new zealand white rabbits, weighing 3.5 kg, were used for this study. equal numbers of animals from both groups were sacrificed ...

Despite advances in surgical techniques, 20% to 90% of rotator cuff (RTC) repairs fail. They tend to fail at the suture-tendon junction due to tension at the repair and gap formation prior to healing. This study evaluated the gap formation and ultimate tensile failure loads of a RTC repair with a decellularized human dermal allograft. Augmentation of a RTC repair with an extracellular matrix gr...

in this study, the role of local injection of butyric acid (ba) with autogenous omental graft was evaluated in healing of experimental achilles tendon injury in rabbits. nine adult male new zealand rabbits were anesthetized and a partial thickness tenotomy was created on both hindlimbs. in treated group, omental graft was secured in place using ba soaked polygalactin 910 suture. in control grou...

Tendons are susceptible to injury, either due to major overload or repeated sublinical injury. Individual fibres can withstand 2-5% strain before undergoing plastic deformation & permanent elongation. Tendons as a whole can withstand up to 20-50% strain, while still demonstrating a linear response and return to normal length. Under normal usage, tendons are strained only to 25-33% of maximum st...

Surgical reattachment of tendon and bone such as in rotator cuff repair, patellar-patella tendon repair and anterior cruciate ligament (ACL) reconstruction often fails due to the failure of regeneration of the specialized tissue ("enthesis") which connects tendon to bone. Tendon-to-bone healing taking place between inhomogenous tissues is a slow process compared to healing within homogenous tis...

BACKGROUND Suture pretension during tendon repair is supposed to increase the resistance to gap formation. However, its effects on the Bunnell suture technique are unknown. The purpose of this study was to determine the biomechanical effects of suture pretension on the Bunnell and cross-lock Bunnell techniques for tendon repair. METHODS Eighty porcine hindlimb tendons were randomly assigned t...

tendon never restores the complete biological and mechanical properties after healing. bone marrow and recently adipose tissue have been used as the sources of mesenchymal stem cells, which have been proven to enhance tendon healing. stromal vascular fraction (svf), derived from adipose tissue by an enzymatic digestion, represents an alternative source of multipotent cells, which undergo differ...

There is currently no method to restore normal function in tendon injuries that result in a gap. The objective of this study was to evaluate the early healing of tendon defects implanted with a porous collagen-glycosaminoglycan (CG) matrix, previously shown to facilitate the regeneration of dermis and peripheral nerve. A novel animal model that isolates the tendon defect site from surrounding t...

BACKGROUND Clinical tendon injuries represent serious and unresolved issues of the case on how the injured tendons could be improved based on natural structure and mechanical strength. The aim of this studies the effect of aquatic activities and alogenic platelet rich plasma (PRP) injection in healing Achilles tendons of rats. METHODS Forty rats were randomly divided into 5 equal groups. Se...