The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease durat...

In contrast to word-level skills, the neural basis of sentence comprehension in children with reading difficulties is not well understood. Using magnetic source imaging, we investigated the spatiotemporal dynamics of regional activity associated with silent passage reading in nonimpaired and students with reading difficulties. The latter exhibited underactivation of the temporoparietal and visu...

Neuroimaging and neuropsychological studies implicate both frontal and temporoparietal cortices when humans reason about the mental states of others. Here, we report an event-related potentials study of the time course of one such "theory of mind" ability: visual perspective taking. The findings suggest that posterior cortex, perhaps the temporoparietal cortex, calculates and represents the per...

IMPORTANCE Cerebrovascular disease and Alzheimer disease (AD) frequently co-occur and seem to act through different pathways in producing dementia. OBJECTIVE To examine cerebrovascular disease and AD markers in relation to brain glucose metabolism in patients with mild cognitive impairment. DESIGN AND SETTING Cohort study among the Alzheimer Disease Neuroimaging Initiative clinical sites in...

The perspective from where the world is perceived is an important aspect of the bodily self and may break down in neurological conditions such as out-of-body experiences (OBEs). These striking disturbances are characterized by disembodiment, an external perspective and have been observed after temporoparietal damage. Using mental own body imagery, recent neuroimaging work has linked perspectiva...

BACKGROUND Patients suffering from Alzheimer's disease exhibit more activity in the conventional electroencephalographic delta and theta bands. This activity concurs with atrophy and reduced metabolic and perfusion rates, particularly in temporoparietal structures. METHODS Whole-head magnetoencephalographic recordings were obtained from 15 patients diagnosed with Alzheimer's disease and 19 he...

This investigation was designed to study the characteristics of a marker for harmonic processing and to test whether it could be used for differentiating harmonic processing capabilities. The ®rst three chords of an ordinary musical cadenca were presented to the left ear to establish a harmonic context followed by a harmonic or non-harmonic target tone. Cadencas were presented rapidly and rando...

OBJECTIVE A randomized double-blind cross-over trial was conducted in patients with persistent auditory hallucinations (AHs) to investigate whether bilateral repetitive transcranial magnetic stimulation (rTMS) at the temporoparietal area or Broca's area is more effective at high- or low-frequencies compared to a sham condition. METHODS Twenty three patients with persistent AHs who remained st...