Background: The illicit vials with street name Temgesic and Norgesic has been distributed in black market of Iran in recent years. With reference to their name, one may presume that they contain the opioid Buprenorphine but there are some reports in opposition to this. True nature of these vials has been shown in the current study. Methods: All of drugs that had been apprehended by law enforce...

Background: The paca is a South American rodent with potential as a commercial food animal. We examined paca placenta as part of a wider effort to understand the reproductive biology of this species. Methods: Thirteen specimens between midgestation and term of pregnancy were studied by light and transmission electron microscopy. Results: The placenta is divided into several lobes separated by i...

A true story Recently a friend of mine (who was also a family planning patient for a while) forgot to take her combined oral contraceptive pill. As a busy detective sergeant in the Metropolitan police and scheduled to work a long weekend, she knew she would not have enough time to go home to take her pill before it became ‘overdue’. Both she and her partner were well motivated to use condoms if...

Lexmaulová L., R. Novotná, P. Raušer, A. Nečas: Complications Related to Surgical Treatment of Intervertebral Disc Disease in Dogs. Acta Vet. Brno 2008, 77: 269-276. After intervertebral disk surgery we often have to deal with various complications (seizures, gastrointestinal tract (GIT) ulcerations, cystitis, and surgical wound healing problems). These complications may lead to the death of th...

Previously, we reported minimal opioid receptor occupancy following a clinical dose of the -opioid agonist, methadone, measured in vivo using positron emission tomography (PET) with [C]diprenorphine and subsequently used rats to obtain experimental data in support of a high receptor reserve hypothesis (Melichar et al., 2005). Here, we report on further preclinical studies investigating opioid r...

We tested the hypothesis that changes in arterial blood flow modify the function of endothelial Ca -activated K channels [calcium-activated K channel (KCa), small-conductance calciumactivated K channel (SK3), and intermediate calcium-activated K channel (IK1)] before arterial structural remodeling. In rats, mesenteric arteries were exposed to increased [ 90%, high flow (HF)] or reduced blood fl...