We aimed to investigate how can target and optimize pulmonary delivery distribution by changing physicochemical characteristics of instilled liquid.Therefore, we created a new liquids group: a. eligible for desired distribution within lung because of assorted physicochemical characteristics b. capable of being augmented with a broad range of chemicals inertly c. no interference on respiratory f...

Assisted mechanical ventilation (MV) may be a favorable alternative to controlled MV at the early phase of acute respiratory distress syndrome (ARDS), since it requires less sedation, no paralysis and is associated with less hemodynamic deterioration, better distal organ perfusion, and lung protection, thus reducing the risk of ventilator-associated lung injury (VALI). In the present review, we...

Mechanical ventilation associated lung injury (VALI) negatively impacts the outcomes of critically ill patients. Research during the past two decades has led to a better understanding of key physiologic mechanisms of injury, yet uncertainty over the topographical distribution of these mechanisms continues to fuel controversies over "best ventilation practice" in injured lungs. In this issue Pav...

Endometriosis is classically defined as the growth of endometrial glands and stroma at extra-uterine sites, most commonly implanted over visceral and peritoneal surfaces within the female pelvis (1). Though endometriosis has been described for the first time in 1690 by the German physician, Daniel Shroen, researchers remain still unsure as to the definitive cause of this disease (2). The most w...

Ventilator-associated lung injury (VALI) is caused by high tidal volume (VT) excursions producing microvascular leakage and pulmonary edema. However, the effects of VALI on lung edema clearance and alveolar epithelial cells' Na,K-ATPase function have not been elucidated. We studied lung edema clearance in the isolated-perfused rat lung model after ventilation for 25, 40, and 60 min with high VT...

The majority of patients with acute respiratory distress syndrome (ARDS) require mechanical ventilation. This support provides time for the lungs to heal, but the adverse effects of mechanical ventilation significantly influence patient outcome. Traditionally, these were ascribed to mechanical effects, such as haemodynamic compromise from decreased venous return or gross air leaks induced by la...

This paper describes a spelling correction system that functions as part of an intelligent tutor that carries on a natural language dialogue with its users. The process that searches the lexicon is adaptive as is the system filter, to speed up the process. The basis of our approach is the interaction between the parser and the spelling corrector. Alternative correction targets are fed back to t...