Aim: To develop a reliable and objective non-touch technique for determination of tear volume and tear secretion by means of tear film fluorophotometry. Methods: 10 defined concentrations of sodium fluorescein were given in an artificial chamber and measured by the Fluorotron Master (Coherent Radiation Inc). A calibration line was established and the calibration equation was programmed into the...

AIM To develop a reliable and objective non-touch technique for determination of tear volume and tear secretion by means of tear film fluorophotometry. METHODS 10 defined concentrations of sodium fluorescein were given in an artificial chamber and measured by the Fluorotron Master (Coherent Radiation Inc). A calibration line was established and the calibration equation was programmed into the...

Extracellular diadenosine polyphosphates play important signaling functions in a number of physiological responses. Here we show that diadenosine polyphosphates are normal constituents of tear fluid and are potent stimulators of tear secretion through their interaction with P2Y receptors. Diadenosine tetraphosphate (Ap(4)A) and Ap(5)A were found in rabbit tears under basal conditions at concent...

This study was performed to evaluate the changes of tear film and ocular surface caused by smoking. Symptom scoring, tear film break-up time (BUT), basal tear secretion test, corneal sensitivity test, keratoepitheliopathy scoring, and conjunctival impression cytology were performed in 29 smokers (58 eyes) and 26 non-smokers (52 eyes). Tear film BUT, basal tear secretion, corneal sensitivity, an...

which either decreases tear production or increases tear evaporation (Figure 1). Increased tear osmolarity is the link between changes in the lacrimal glands and lids, and disease of the ocular surface. Studies of pre-clinical models of lacrimal gland disease and meibomian gland dysfunction show that the ocular surface changes of dry eye disease are dependent upon and proportional to increases ...

PURPOSE The purpose of the present study was to investigate the roles of caspase 1 and extracellular signal-regulated kinase (ERK) in inflammation-induced inhibition of lacrimal gland secretion. METHODS Lacrimal gland inflammation was induced by injection of lipopolysaccharide (LPS; to study the role of caspase 1) or IL-1beta (to study the role of ERK). Lacrimal gland protein secretion was me...

purpose : the main ocular manifestation of rheumatoid arthritis is dry eye. lacritin is a secreted glycoprotein of tear and when applied topically in rabbits, it increased the volume of basal tear secretion. so the aim of this study was to compare lacritin level in rheumatoid arthritis (ra) and control group. methods : this cross-sectional study was done on 40 patients with ra and 48 healthy su...

PURPOSE To measure the increase in tear secretion evoked by selective stimulation of the different populations of sensory receptors of the cornea and conjunctiva by using moderate and intense mechanical, chemical, and cold stimuli. METHODS Six healthy subjects participated in the study. Tear secretion was measured in both eyes by the Schirmer's test conducted under control conditions and afte...