نتایج جستجو برای: tcells
تعداد نتایج: 170 فیلتر نتایج به سال:
There has been much progress in the identification of genes and molecular pathways involved in the pathogenesis of type 1 diabetes. Human histocompatibility (HLA) complex genes are the most powerful susceptibility determinants. The stronger effect is from alleles coding for selected HLA class I and class II antigen-presenting molecules, which are restricting elements for autoreactive CD8 and CD...
In the leukocyte adherence inhibition (LAI) assay, about 34% of adherent T-cells from patients with breast cancer exhibit nonadherence to glass when incubated with extracts of autologous cancer but not with HLA-A, -B, and -C mismatched extracts of breast cancer. To determine whether the recognition by Tcells of tumor antigen was major histocompatibility complex restricted, major histocompatibil...
Objective/purpose In asthma, CD4+T cells are selectively recruited into the bronchial mucosa. CD4+ T cells consist of different subsets that express lineage specific transcription factors and play different roles either in initiating and supporting the development of immune response, but also in orchestrating and regulating them. The aim of our study was to evaluate the effect of T cells-bronch...
Methods Patients on highly active antiretroviral therapy (HAART) with long-term suppressed viremia were selected and divided according to treatment: switched to RAL vs. maintained the same regimen (control group). Samples were collected at the time of RAL switch (0) and six months after (+6). Immune parameters were assessed in peripheral blood mononuclear cells (PBMCs) using fivecolour flow cyt...
Background We’ve previously shown that radiotherapy (RT) converts poorly immunogenic tumors resistant to antibodies (mAbs) against the immune checkpoint receptor CTLA-4 into susceptible ones (Demaria et al., 2005; Dewan et al., 2009). Programmed death-1 (PD-1) is another immune checkpoint receptor upregulated on T-cells shortly after activation and expressed at high levels on exhausted Tcells. ...
In this paper we propose and study models of long-term Human Immunodeficiency Virus (HIV-1) infection. Our aim is to identify model mechanisms that allow to explain the trends observed in clinical measurements of the number of CD4+ Tcells and virus throughout the long-term HIV-1 infection, from the acute phase until the onset of AIDS. To achieve our goal we apply some standard methods of modeli...
The adaptive immune system has evolved in vertebrates to eliminate invasive pathogens and malignantly transformed cells. Proteins are degraded in the cytoplasm by the proteasome. Subsequently, the peptides are transported from the cytoplasm into the lumen of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP) where they are loaded on MHC class I molecules....
Methods Randomised, multicentre, proof-of-concept study enrolling 100 pts divided into 2 arms (1:1), A:HAART+MVC, B:HAART. Inclusion criteria were: CD4 count ≥200 cells/μL and/or a recovery of CD4 cells <25% compared to the HAART initiation and with a stable virologic suppression after 1 year of HAART. Ultrasensitive HIVRNA was quantified via Amplicor HIV-1 Monitor Kit v1.5. Naive CD45RA+, memo...
Preeclampsia is associated with oxidative stress, which is suspected to play a role in hypertension, placental ischemia, and fetal demise associated with the disease. Various cellular sources of oxidative stress, such as neutrophils, monocytes, and CD4(+) T cells have been suggested as culprits in the pathophysiology of preeclampsia. The objective of this study was to examine a role of circulat...
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