BACKGROUND Paclitaxel-eluting stents decrease angiographic and clinical restenosis following percutaneous coronary intervention compared to bare metal stents. TAXUS Element is a third-generation paclitaxel-eluting stent which incorporates a novel, thinner-strut, platinum-enriched metal alloy platform. The stent is intended to have enhanced radiopacity and improved deliverability compared to oth...

OBJECTIVES This study sought to study stent thrombosis with the paclitaxel-eluting Taxus stent. BACKGROUND The incidence and timing of stent thrombosis after drug-eluting stent placement compared with bare-metal stent implantation remain unsettled, with consequent uncertainty about risk stratification and long-term recommendations for antiplatelet medications. METHODS This study used a pati...

Early results with polymer-based paclitaxel-eluting stents have shown significant improvements in the clinical and angiographic parameters of restenosis, as well as excellent safety outcomes. However, the duration of these beneficial effects is unknown. Therefore, the clinical outcomes of the TAXUS I study population were evaluated at 2- and 3-year follow-up. In TAXUS I, 61 patients with single...

The Taxus cuspidate has been used as a traditional Chinese medicinal herb and considered to affect various physiological functions in the body for thousands of years. As we know that taxol isolated from the Taxus cuspidate has been approved for the treatment of ovarian cancer, it has also shown its antitumor abilities against other kinds of cancers. But the antitumor activity of other component...

OBJECTIVES The aim of this research was to assess the efficacy of paclitaxel-eluting stents in chronic total coronary occlusions (CTO). BACKGROUND Percutaneous coronary interventions for CTOs are characterized by a high target vessel failure rate. METHODS In 48 consecutive patients, paclitaxel-eluting stents (Taxus, Boston Scientific Corp., Natick, Massachusetts) were implanted after succes...

A cladistic analysis of the medicinal plant Taxus, using the sequences of one chloroplast (trnS-trnQ spacer) and three nuclear taxadiene synthase (TS), 10-deacetylbaccatin III-10beta-O-acetyltransferase (DBAT), and 18S rDNA) molecular markers, was carried out by distance, parsimony, likelihood, and Bayesian methods. Three of the four New World species (T. brevifolia, T. floridana and T. globosa...

In Canada, three subspecies of American badgers (Taxidea taxus (Schreber, 1777)) traditionally are identified; two of which are listed as endangered because of their restricted geographic range and low population sizes. To verify their subspecific designations and genetic insularity, we analyzed mitochondrial control region sequences within and among badger subspecies (Taxidea taxus jacksoni Sc...

CONTEXT Taxine-derived alkaloids, taxane-derived substances, and glycosides seem to be responsible for the toxicity of Taxus spp. by blocking microtubule, sodium and calcium channels causing conduction abnormalities. Cases with Taxus baccata acute intoxication have rarely been reported. CASE DETAILS We report the case of a 43-year-old man who ingested, for suicidal purposes, common (or Europe...

INTRODUCTION AND OBJECTIVES This article examines the cost impact associated with the utilization of the Taxus drug eluting stent versus a conventional bare-metal stent for percutaneous coronary interventions in a Spanish hospital setting. METHODS A decision analysis model has been developed to compare the intervention and re-hospitalization costs at 12 and 24 months post-intervention. The an...