نتایج جستجو برای: taxotere
تعداد نتایج: 880 فیلتر نتایج به سال:
Constitutive activation of Akt or nuclear factor-kappaB (NF-kappaB) has been reported to play a role in de novo resistance of cancer cells to chemotherapeutic agents, which is a major cause of treatment failure in cancer chemotherapy. Previous studies have shown that 3,3'-diindolylmethane (DIM), a major in vivo acid-catalyzed condensation product of indole-3-carbinol, is a potent inducer of apo...
Constitutive activation of Akt or nuclear factor-KB (NF-KB) has been reported to play a role in de novo resistance of cancer cells to chemotherapeutic agents, which is a major cause of treatment failure in cancer chemotherapy. Previous studies have shown that 3,3¶-diindolylmethane (DIM), amajor in vivo acid-catalyzed condensation product of indole-3-carbinol, is a potent inducer of apoptosis, i...
BACKGROUND Nanosomal docetaxel lipid suspension formulation was developed to eliminate ethanol and polysorbate 80 from the currently used docetaxel (Taxotere) drug for treatment of cancer patients. NDLS clinical safety and efficacy was evaluated and compared with Taxotere at 75 mg/m(2) in metastatic breast cancer patients. PATIENTS AND METHODS A total of 72 patients were randomized in a ratio...
The gastrin gene is expressed widely in pancreatic adenocarcinomas and the study aimed to assess its role in both the resistance of cancer cells to apoptosis and the sensitivity of cells to chemotherapeutic agents. Two human pancreatic cell lines, PAN1 and BXPC3, expressed gastrin at both the RNA and protein levels and are shown to be representative of human pancreatic adenocarcinomas in terms ...
The gastrin gene is expressed widely in pancreatic adenocarcinomas and the study aimed to assess its role in both the resistance of cancer cells to apoptosis and the sensitivity of cells to chemotherapeutic agents. Two human pancreatic cell lines, PAN1 and BXPC3, expressed gastrin at both the RNA and protein levels and are shown to be representative of human pancreatic adenocarcinomas in terms ...
سابقه و هدف : دو داروی taxotere و xeloda هر کدام به تنهایی در بیماران سرطان پستان متاستاتیک داروهای موثری می باشند. در بعضی مطالعات آزمایشگاهی اثرات سینرژیک این دو دارو در سرطان پستان ثابت شده است. ما در این مطالعه بیماران مبتلا به سرطان پستان متاستاتیک را که قبلا هیچکدام از این دو دارو را دریافت نکرده بودند با ترکیبی از این دو دارو درمان نموده و نتایج درمانی و عوارض آن را تعیین نمودیم. مواد ...
Nanoparticulation of insoluble drugs improves dissolution rate, resulting in increased bioavailability that leads to increased stability, better efficacy, and reduced toxicity of drugs. Docetaxel (DTX), under the trade name Taxotere™, is one of the representative anticancer chemotherapeutic agents of this era. However, this highly lipophilic and insoluble drug has many adverse effects. Our nove...
This is a phase II study to determine the efficacy and toxicity of intravesical Taxotere in conjunction with Bacillus Calmette-Guérin (BCG)-Interferon Alpha IIB (IFN) in the treatment of recurrent superficial transitional cell carcinoma (TCC) of the urinary bladder. The purpose of this trial is to see whether the addition of intravesical Taxotere to BCG-INF increases disease-free survival by a ...
Abstract Background Cancer remains one of the leading causes death worldwide. Docetaxel, first marketed as ‘Taxotere’, has been approved for use a chemotherapeutic management gastric, breast, neck, head, non-small cell lung cancer and prostate cancer. Main body Taxotere, is docetaxel formulation solubilized in tween 80 13% ethanol solution. It effective agent but numerous toxic effects due to p...
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