Purpose: The objective of this study was to investigate the total antioxidant status (TAS) and DNA damage markers of serum and aqueous humor in patients with pseudoexfoliation (PEX) syndrome. Methods: Twenty-seven cataract patients with PEX and twenty-seven without PEX syndrome were included in the study and groups were matched for age and gender. Patients had no elevated intraocular pressure (...

Topographic attributes (TAs) play an important role in quantitatively describing the characteristics of landform and its structure. At present, TAs are classified from different views by many scientists being from various fields. However, there are still some urgent problems that need to be clarified about TAs. The relationships and differences of various TAs are not revealed and a mature, wide...

Meme kanseri dünyada sık görülen ölüm nedenleri arasında yer almaktadır, etyolojisinde genetik, endokrin ve çevresel faktörlerin rol aldığı bilinmektedir. tedavisine yönelik yeni ajanların geliştirilmesi ya da varolan ilaçların etkinliğinin arttırılması için beslenmede takviye gıdaların alımı önem taşımaktadır. Deniz ürünleri, baklagiller, et, süt, kabuklu yemişler gibi bitkisel hayvansal gıdal...

BACKGROUND Arsenic exposure is a risk factor for atherosclerosis in adults, but there is little information on arsenic and early risk biomarkers for atherosclerosis in children. Carotid intima-media thickness (cIMT) is an indicator of subclinical atherosclerotic burden that has been associated with plasma asymmetric dimethylarginine (ADMA), a predictor of cardiovascular disease risk. OBJECTIV...

purpose : the objective of this study was to investigate the total antioxidant status (tas) and dna damage markers of serum and aqueous humor in patients with pseudoexfoliation (pex) syndrome. methods : twenty-seven cataract patients with pex and twenty-seven without pex syndrome were included in the study and groups were matched for age and gender. patients had no elevated intraocular pressure...

Gallic acid is a phenolic compound found in many plant sources with strong antioxidant activity. In this study, the bioactivity of was investigated Japanese quails induced by oxidative stress. The study performed on four groups 40–day–old male quail (Coturnix japonica). Oxidative stress created for 1 week adding 0.5% hydrogen peroxide. terminated administering 100 mg·kg-1 body weight intraperit...

Two Telomeric Associated Sequences, TAS-R and TAS-L, form the principal subtelomeric repeat families identified in Drosophila melanogaster. They are PIWI-interacting RNA (piRNA) clusters involved in repression of Transposable Elements. In this study, we revisited TAS structural and functional dynamics in D. melanogaster and in related species. In silico analysis revealed that TAS-R family membe...

VEGF receptor (VEGFR) signaling plays a key role in tumor angiogenesis. Although some VEGFR signaltargeteddrugshavebeen approved for clinical use, their utility is limitedbyassociated toxicities or resistance to such therapy. To overcome these limitations, we developed TAS-115, a novel VEGFR and hepatocyte growth factor receptor (MET)-targeted kinase inhibitor with an improved safety profile. T...

Many pharmaceutical companies worldwide specialize in oncology drug development and marketing. Among them, we have continued to take up the challenge of understanding the metabolism of pyrimidines as essential components of deoxyribonucleic acid for many years, and have provided unique products such as UFT(®) and TS-1 for cancer patients. Using our cumulative experience and knowledge, we are cu...