Background: Fluoride-18 is the most widely used radioisotope for Positron Emission Tomography (PET). [18F] 2-flouro- 2-deoxy D-glucose (FDG) has become a standard tool in the area of clinical research. The oxygen-18 enriched water is the most widely used target for the production of fluoride-18. The use of the nuclear reaction 18O (p,n)18F has been found as the most effective method for the pro...

background: fluoride-18 is the most widely used radioisotope for positron emission tomography (pet). [18f] 2-flouro- 2-deoxy d-glucose (fdg) has become a standard tool in the area of clinical research. the oxygen-18 enriched water is the most widely used target for the production of fluoride-18. the use of the nuclear reaction 18o (p,n)18f has been found as the most effective method for the pro...

Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.

the chemistry of 2-oxo-1,2,3,4-tetrahydropyrimidines began to develop toward the end of 1893 year, when the first representatives of this class compounds were reported by p. biginelli. despite prior reports of several really effective catalytic and non-catalytic approaches towards biginelli-type products, an overwhelming number of new catalysts for the biginelli reaction have been recently publ...