Diabetic Nephropathy: Mechanisms of Renal Disease Progression YASHPAL S. KANWAR,* JUN WADA, LIN SUN,* PING XIE,* ELISABETH I. WALLNER, SHELDON CHEN, SUMANT CHUGH, AND FARHAD R. DANESH *Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois 60611; Department of Medicine, Okayama University School of Medicine, Okayama, 700-8558 Japan; and Department of Medicine, No...

Background and Objectives: Different studies carried out mainly in young non-consuming children of alcoholics show an association of P300 abnormalities with alcoholism and with the TaqI-A1 allele. Since the relationship between P300 and the TaqIA1 allele has not been specifically studied in alcoholic patients, our objective was to investigate whether the association exits in this population. Me...

Metal cofactors (Mg and Mn) modulate both specific DNA binding and strand cleavage in the TaqI endonuclease (Cao, W., Mayer, A. N., and Barany, F. (1995) Biochemistry 34, 2276–2283). This work attempts to establish the structural basis of TaqI-DNA-metal interactions using an affinity cleavage technique. The protein was cleaved by localized hydroxyl radicals generated by oxidizing Fe within the ...

Introduction: Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator of glucose metabolism in mice. Moreover, OC level is decreased in patients w...

We examined the cholesteryl ester transfer protein (CETP) gene TaqI intron 1 B1/B2 polymorphism and the -629A/C CETP promoter polymorphism in respect to high-density lipoprotein cholesterol (HDL-C) in a healthy Iranian population taken from the Tehran Lipid and Glucose Study (TLGS). The relationship between CETP activity and HDL-C level was also determined along with body mass index, blood pres...

BACKGROUND Genetic variants of proteins involved in lipid metabolism may play an important role in determining the susceptibility for complications associated with type II diabetes mellitus (T2DM). Goal of the present study was to determine the association of cholesteryl ester transfer protein TaqI B, D442G, and APOE Hha I polymorphisms with T2DM and its complications. METHODS Study subjects ...

Although a number of studies have been conducted to determine the association between vitamin D receptor (VDR) TaqI polymorphism and periodontitis in the Chinese population, this association remains elusive. To assess the influence of VDR TaqI polymorphism on the risk of periodontitis, a meta-analysis was performed in a Chinese population. Relevant studies were identified using the databases Pu...

Bu çalışmada Simental sığır ırkına ait toplam 202 hayvanda STAT5A-AvaI ve MYF5-TaqI polimorfizmleri ile günlük süt verimi arasındaki ilişkinin araştırılması amaçlanmıştır. PZR tekniği çoğaltılan 215 bç uzunluğundaki STAT5A gen bölgesi AvaI restriksiyon enzimi kesilirken, 512 MYF5 TaqI kesilmiştir. Belirlenen genotipleri laktasyon verimleri ilişki Tek Yönlü Varyans Analizi (ANOVA) değerlendirilm...

BACKGROUND In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children. METHODS Our study included 380 Chinese children aged 4-7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP. RESULTS The adjusted logistic regression an...

OBJECTIVE Linkages of renin gene polymorphisms with hypertension have been implicated in several populations with contrasting results. Present study aims to assess the pattern of renin gene polymorphisms in Bangladeshi hypertensive individuals. METHODOLOGY Introns 1, 9 of renin gene and 4063 bases upstream of promoter sequence of renin gene were amplified from the genomic DNA of the total 124...