Background: The aim of this work was to investigate whether Follistatin like 1 (FSTL1) exerted an effect on acute kidney injury (AKI) induced by sepsis, and explore the molecular mechanism. Methods: A cecal ligation puncture (CLP) model established adenoviral solution administrated newborn rats achieve FSTL1 knockdown. Colorimetric assays measured concentrations serum creatinine blood urea nitr...

Hyperuricemia correlates with the development and progression of renal diseases. We have previously revealed that uric acid (UA) initiates immune responses through toll like receptors (TLR)4 dependent Nod-like receptor protein (NLRP) 3 inflammasome formation and interleukin (IL)-1β processing, as well as major human leukocyte antigen (HLA)-DR (surface receptor for major histocompatibility compl...

Abstract Background To investigate the relationship between levels of serum adipokine retinol-binding protein 4 (RBP4) and essential hypertension as well to explore role mechanism RBP4-induced activation renin–angiotensin system (RAS) in adipocyte. Methods From December 2016 March 2019, 96 hypertensive patients without treatment 64 healthy nonhypertensive subjects were recruited. The difference...

BACKGROUND Femoral head osteonecrosis is frequently observed in patients treated with excessive corticosteroids. The objective of the current study was to establish a rat model to investigate the disruption of immune response in steroid-induced femoral head osteonecrosis via Toll-like receptor 4 (TLR4) signaling pathway. METHODS Male SD rats were divided into the treatment group (group A) and...

NLRP6 inflammasome, one of the important intracellular innate immune sensors, has been shown to regulate immune responses. However, its roles in the intracerebral hemorrhage (ICH) are completely not clear. In the present study, we investigated the expression profile and biological roles of NLRP6 inflammasome in perihematomal brain tissues of mice subjected to ICH. In this study, we investigated...

Inflammatory injury of the endothelium leads to apoptosis and endothelial dysfunction. The current study explored the effect and mechanisms of paeonol in inflammation-induced apoptosis and endothelial dysfunction induced by lipopolysaccharides (LPSs). The effects of paeonol on LPS-induced inflammatory injury were assessed by Western blotting, flow cytometry and reactive oxygen species (ROS) mea...

The study aims to investigate the underlying mechanism involved in the early secretory antigenic target-6 (ESAT-6) in renal injury through regulation of the expression of miR-155 through the oll-like receptor (TLR)-4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling pathway in Mycobacterium tuberculosis (MTB)-infected mice. Sixty C57BL/6 mice with MTB-induced renal injury were randomly...

OBJECTIVE To determine if serum amyloid A (A-SAA) could be detected in human osteoarthritic (OA) joints and further clarify if high A-SAA level in joints result from a local production or from a diffusion process from abnormally elevated plasma concentration. Regulatory mechanism of A-SAA expression and its pro-inflammatory properties were also investigated. METHODS A-SAA levels in serum and ...

•Carnivorans lack key NLRs and express a unique caspase-1/-4 hybrid protein•This protein is defective in mediating activation of common inflammasome pathways•What little activity occurs driven by caspase-8, rather than Zoonotic pathogens, such as COVID-19, reside animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity host immune ge...