INTRODUCTION Although tableting is one of the most commonly used processes in drug manufacturing, the tablet formation process is still not fully understood, nor can it be fully controlled. AREAS COVERED In this paper, recent approaches to correlate tablet mechanical properties with process parameters are discussed, covering (mainly) the last 5 years. These approaches are the basis for a futu...

Upon the adoption of an external lubrication system (ELS) for tableting, control of the content uniformity of lubricant among tablets and its distribution on the tablet surface becomes extremely important. An energy-dispersion X-ray analyzer (EDX) attached to a scanning electron microscope was used to assess these parameters. The content of magnesium stearate (Mg-St) on the tablet surface signi...

Multiple unit controlled release dosage forms offer various advantages over their single unit counterparts. Most of these advantages are associated with the uniform distribution of multiparticulates throughout the gastrointestinal tract. Though coated pellets can be filled into hard gelatin capsules, tablet formulation is the preferred one because of various advantages associated with it. Howev...

This study investigates the effect of particle size on the compression characteristics of wet- (fluid-bed granulation - FBG) and dry-granulated (slugging - DGS) tableting mixtures. Particle-size distribution, flowability, compressibility, using the Heckel and Walker model, compactibility and elastic recovery as well as friability and disintegration were determined and compared between the two p...

A quality-by-design (QbD) principle, including process analytical technology, is becoming the principal idea in drug development and manufacturing. The implementation of QbD into product development and manufacturing requires larger resources, both human and financial, however, large-scale production can be established in a more cost-effective manner and with improved product quality. The objec...

The conventional tableting method used involves first making granules and then compressing into tablets, but the need in recent years for process validation, GMP and automation of production processes has focused renewal of attention on the direct tableting, which involves few steps [1]. Zaltoprofen, is a novel NSAID, selective COX2 inhibiting drug used in the treatment of rheumatoid arthritis ...

Direct compression is able to produce tablets at a lower cost than wet granulation and tableting method, due to a fewer items of process validation. In this study, acetaminophen was used as a medicine with various granular diameters to formulate tablets by direct compression, thus evaluating their physical properties. Consequently, direct compression was found effective in formulating tablets w...

The paper proposes a near infrared method able to directly and simultaneously quantify ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets without any sample preparation. In the first step, calibration models for the quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and subsequently in chewable vitamin C tablets (...

Compression of powders and granules into cohesive mass is a complex and irreversible dynamic process. Mechanically, the compaction process consists of progressive strain on the powder mixture confiding it to a final volume and porosity. Compression of pellets into the tablet form is more complex. It should be taken into consideration not only pellets properties (their compressibility, shape, po...

Analysis of piracetam polytypes using energy-vector models, thermal expansion and nanoindentation measurements, produces a plausible link between their crystal structures tableting behaviour.