Address correspondence and requests for reprints to: Leonidas H. Duntas, M.D., Endocrine Unit, Evgenidion Hospital, University of Athens, 20 Papadiamantopoulou Str., 11528 Athens, Greece, e-mail: [email protected] Received 16-03-05, Accepted 30-03-05 mainly owing to lesser affinity of the serum binding proteins for T3. At times T3 has been added at various dosages or as a fixed preparation, cont...

In rats, the respective contribution of the thyroid and peripheral tissues to the pool of T3 remains unclear. Most, if not all, of the circulating T3 produced by extrathyroidal sources is generated by 5'-deiodination of T4, catalyzed by the selenoenzyme, type I iodothyronine 5'-deiodinase (5'D-I). 5'D-I in the liver and kidney is almost completely lost in selenium deficiency, resulting in a mar...

Receptors for thyrotropin-releasing hormone (TRH) are present on mouse pituitary thyrotropic tumor cells. Incubation of thyrotropes with 100 nM TRH or 4 nM L-triiodothyronine (T3) for 48 h decreased the number of TRH receptors to approximately equal to 50 and 20% of control, respectively. There was no effect on the equilibrium dissociation constant which was 3-5 nM. The depletion in the number ...

Our objective was to determine the effect of level and chemical form of dietary selenium on productivity of beef cows, concentrations of triiodothyronine (T3), and thyroxine (T4) in plasma, and immunoglobulins (IgG and IgM) in plasma and colostrum of cows. Pregnant cows (n = 60) were randomly allocated among four dietary treatments of 20, 60, or 120 ppm Se as selenite and 60 ppm as selenomethio...

BACKGROUND Increased BMI may increase the body's capacity to store potent inhaled anaesthetics, more so with more soluble agents. Accordingly, we asked whether increased BMI and longer anaesthesia prolonged airway reflex recovery. METHODS We measured time from anaesthetic discontinuation until first response to command (T1); from response to command until ability to swallow (T2); and from ana...

The T3 complex has been defined by a group of monoclonal antibodies which react with all human peripheral blood T lymphocytes and a subpopulation of thymocytes. This membrane structure includes glycoproteins of 44 (alpha), 37 (beta), 25 (gamma), and 20 kDa (delta) as well as a nonglycosylated polypeptide of 20 kDa (epsilon). The characterization of the alpha and beta chains has been of particul...

in this study, a landrace melon zarde jalali as the scion and commercial varieties of cucurbita rootstocks cv., shintozwa and ferro-rz was used as the rootstock. grafted plants upon commercial varieties of cucurbita with own-rooted and ungrafted at three irrigation levels of 60, 80 and 100% (respectively 4984.32, 6124.82 and 7239.41 m3ha-1) based on total available water depletion with drip irr...

INTRODUCTION. It has been shown that inflammation affects thyroid function. In patients with end-stage renal disease, low plasma triiodothyronine (T3) may be an unsuspected expression of the inflammatory state of these patients. This study evaluated the correlation between T3 and high-sensitivity C-reactive protein (HSCRP) levels in patients on peritoneal dialysis (PD) and hemodialysis. MATERIA...

We evaluated the effects of temperature and humidity on thyroid hormones (T4, T3) and thyrotropin (TSH) measured in blood spots dried on filter paper. RIAs for T4 and T3 blood spots were optimized to measure these analytes over the neonatal and euthyroid adult reference intervals. Sensitivities of the T3 and T4 assays were 0.5 and 10 nmol/L, respectively. A blood-spot immunoradiometric assay fo...

Side effects after the first administration of OKT3, a murine anti-CD3 monoclonal antibody (mAb) of the IgG2a class, are largely attributed to the release of cytokines as a result of T cell activation caused by interaction with Fc receptors (FcR) on human monocytes. As human monocytes possess FcR for murine IgG2a but not for IgA, it is expected that an anti-CD3 mAb of the IgA class causes less ...