The striatum plays an important role in "habitual" learning and memory and has been hypothesized to implement a reinforcement-learning algorithm to select actions to perform given the current sensory input. Many experimental approaches to striatal activity have made use of temporally structured tasks, which imply that the striatal representation is temporal. To test this assumption, we recorded...

BXSB mice have an approximately 40-60% incidence of neocortical ectopias in layer I of the prefrontal/motor cortex. Prior studies have found major behavioral differences between those with ectopias and their non-ectopic littermates. Some of these findings indicate that the two groups differ with respect to spatial reference and working memory. The purpose of this study was to measure reference ...

in this study the effects of 5-ht2a receptor blockers in ca1 region of rat hippocampus on spatial learning were assessed in a t-maze, a spatial discrimination task. rats were connulated and bilateral injection of vehicle (saline) and 5-ht2a- selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) were injected through the connulae 30 miutes before training each day. results indicated that ...

This study examined the effects of social housing manipulations on bodyweight, corticosterone levels, and performance of T-maze alternation in male CD-1 mice. Males that adopted a dominant social rank were heavier than those that adopted a subordinate social rank. Dominant males also had lower corticosterone concentrations than the subordinates. However, there was little to suggest that these p...