Nuclear transcription factor B (NF-B) regulates innate and adaptive immunity functions mediates inflammatory responses by activating proinflammatory cytokine gene transcription. TNF inhibitors block the NF-B signaling pathway, thus reducing activity. The aim of study was to evaluate informativity NF-kB determination in lymphocyte populations children with bowel disease (IBD) psoriasis assess ef...

BACKGROUND Chronic obstructive pulmonary disease and emphysema are a frequent result of long-term smoking, but the exact mechanisms, specifically which types of cells are associated with the lung destruction, are unclear. METHODS AND FINDINGS We studied different subsets of lymphocytes taken from portions of human lungs removed surgically to find out which lymphocytes were the most frequent, ...

In this work we use a combination of statistical physics and dynamical systems approaches, to analyze the response to an antigen of a simplified model of the adaptive immune system, which comprises B, T helper and T regulatory lymphocytes. Results show that the model is remarkably robust against changes in the kinetic parameters, noise levels, and mechanisms that activate T regulatory lymphocyt...

ent pathogens; these mechanisms are mainly secondary to the activation of B lymphocytes and of humoral immunity, or to the activation of cell-mediated immunity. Activation of B lymphocytes, and production of antibodies has been shown to be more useful in defense against cell-free agents and toxins (e.g., pneumococcus; tetanus toxins). In contrast, triggering of cell-mediated immunity appears to...

An experimental condition was established in vivo for selectively eliminating hapten-reactive suppressor T-cell activity generated in mice primed with a para-azobenzoate (PAB)-mouse gamma globulin (MGG)-conjugate and treated with PAB-nonimmunogenic copolymer of D-amino acids (D- glutamic acid and D-lysine; D-GL). The elimination of suppressor T-cell activity with PAB-D-GL treatment from the mix...

A patient with S#{233}zary syndrome presented with disease limited to the skin and circulating abnormal lymphocytes but subsequently developed a diffuse undifferentiated lymphoma. Malignant cells from a lymph node effaced with the morphologically undifferentiated lymphoma were characterized as being of thymus-derived (T cell) origin. We have previously shown that circulating malignant lymphocyt...

Effector functions in the immune system are carried out by a variety of cell types, and as our understanding of the complexity of the system expands, the number of recognized subdivisions of cell types also continues to increase. B lymphocytes, producing antibody, were initially distinguished from T lymphocytes, which provide help for B cells (1, 2). The T-cell population was further divided wh...