a central role for t cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. the goal of this study is to summarise currently available data on the importance of t cells in psoriasis pathogenesis. a  systematic  review  of  the  english  medical  literature  was  conducted  by  searching pubmed, embase, isi w...

helicobacter pylori (h. pylori) is a gram-negative bacterium that colonizes the human stomach and affects more than half of the global human population. this microorganism shows variations in its geographical distribution and causes chronic gastritis, peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. the development of these clinical entities depends on the ba...

interleukin-4 (il-4) is produced by t-helper cells type 2 (th2) and induces ige synthesis. t-helper cells type 1 (th1) produce interferon-gamma (ifn-gamma) which suppresses th2 and reduces il-4 induced ige production. in this :;tudy , we demonstrated that the levels of specific ige in the serum of atopic children (n=20) were elevated while il-4 production was increased and ifn-gamma secretion w...

all-trans retinoic acid (atra), as an active metabolite of vitamin a, has been shown to affect immune cells. this study was performed to evaluate the effect of atra on viability, proliferation, activation and lineage-specific transcription factors of cd4+ t cells. cd4+ t cells were  separated  from  heparinized  blood  of  healthy  donors  and  were  cultured  in conditions, some with, some wit...

One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...

Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral blood naïve CD4+ T cells were co-cultured with ASCs derived from breast cancer or normal breast ...

stem cells from human exfoliated deciduous teeth (shed) have been introduced recently and  possess characteristics similar to  mesenchymal stem  cells (mscs). because of  their convenient accessibility and safety of harvest, shed can be a preferable source for the ever- increasing mscs’ applications. while they are new, their immunoproperties have not been adequately studied. in this study, we ...

multiple sclerosis (ms) is an inflammatory demyelinating and neurodegenerative disorder of  the  central  nervous  system (cns), which mainly affects  young adults. activated t lymphocytes promote the neuro-inflammatory cascade of ms by secreting pro-inflammatory cytokines and play a significant role in its pathogenesis. t  lymphocytes may trigger the inflammation, which in turn leads to axonal...

atherosclerosis is a chronic inflammatory condition that affects the arterial wall. oxidized low- density lipoprotein (ox-ldl) seems to have an important role in atherosclerotic plaque formation. this study was performed to investigate the effects of ox-ldl as well as pha on proliferation and gene expression of  peripheral blood  mononuclear  cells (pbmcs) in patients with atherosclerosis compa...