INTRODUCTION Recent literature proposes that amyloid β (Aβ) and phosphorylated tau (p-tau) synergism accelerates biomarker abnormalities in controls. Yet, it remains to be answered whether this synergism is the driving force behind Alzheimer disease (AD) dementia. METHODS We stratified 314 mild cognitive impairment individuals using [18F]florbetapir positron emission tomography Aβ imaging and...

AIM The in vitro activity of colistin in combination with sulbactam, netilmicin, and vancomycin against colistin-resistant A. baumannii strains was investigated. Furthermore, the clonal relationship of the strains was analyzed. METHODS Clonal relationship was investigated using rep-PCR. To screen for synergysm, the fractional inhibitory concentration index (FICI) was calculated using checkerb...

Hydroxy isothiocyanates, especially 2-(4-hydroxyphenyl)ethyl isothiocyanate (hITC), were examined for antimicrobial synergism with streptomycin (SM) against Escherichia coli. On the course of those experiments, a peculiar suppression of SM by a low concentration of hITC was observed, besides the antibacterial synergism of hITC with SM. Further, bactericidal activity of SM in physiological salin...

Plant diseases are often thought to be caused by one species or even by a specific strain. Microbes in nature, however, mostly occur as part of complex communities and this has been noted since the time of van Leeuwenhoek. Interestingly, most laboratory studies focus on single microbial strains grown in pure culture; we were therefore unaware of possible interspecies and/or inter-kingdom intera...

The purpose of this study was to determine the effects of the vasoactive perivascular neuropeptide substance P (SP) on the growth and function of vascular endothelial cells in serum-free culture conditions with cells quiescent in the GO-G, phase of the cell cycle and to characterize the response. In addition, interactions between SP and other growth factors and neuropeptides including insulin, ...

antimicrobial synergism with streptomycin (SM) against Escherichia coli. On the course of those experiments, a peculiar suppression of SM by a low concentration of hlTC was observed, besides the antibacterial synergism of hlTC with SM. Further, bactericidal actiyity of SM in physiological saline was reduced by addition of hlTC. Time course experiments proyed that the antagonistic effect of hlTC...

Various concepts of interaction are reconsidered in light of a sufficient-component-cause framework. Conditions and statistical tests are derived for the presence of synergism within sufficient causes. The conditions derived are sufficient but not necessary for the presence of synergism. In the context of monotonic effects, the conditions derived are closely related to effect modification on th...

The mutual enhancement of the effect of insulin release by glucose and amino acids is not clearly understood. Present in vitro studies with isolated rat islets were undertaken to elaborate the role of amino acids on insulin release, particularly their interaction with glucose as well as among each other, which has been reported to lead to synergism in the human subjects. In the presence of 8.3 ...

The corrosion inhibition performance of acetylacetonate complexes of zinc(II), manganese(II), cobalt(II) and copper(II) on the mild steel substrate in 1M H3PO4 was studied using DC polarization. It was seen that the mentioned complexes decreased corrosion rate of mild steel in phosphoric acid media due to the adsorption on metal surface. The potential of mild steel shifted toward more active po...