developmental disturbances of the tongue (aglossia, macroglossia, microglossia, and ankyloglossia) can adversely affect the development of the surrounding structures including the palate, alveolar process, and teeth. these developmental disturbances impair functions such as mastication, speech, and swallowing. ankyloglossia is of various types and may be associated with other syndromic features...

introduction: cleft lip (cl) and cleft palate (cp) are among the most common congenital anomalies. constituting 65% of head and neck anomalies in isolated or syndromic forms, they are considered as the most common head and neck congenital deformities in children. methods: 15 children from the tabriz children hospital were evaluated in this descriptive-analytic cross sectional study that possess...

hyperdontia or supernumerary teeth in both arches without any syndromic manifestation are extremely rare. supernumerary teeth are commonly associated with gardner’s syndrome, cleft lip and palate, cleidocranial dysplasia and trichorhinophalangeal syndrome. five cases of non-syndromic multiple premolars of maxillary and mandibular arches in indian patients are presented here. this case series re...

Cleft lip and cleft palate are one of the most frequent congenital anomalies worldwide. This study was conducted in order to measure the frequency of cleft lip and palate among live births in Akbar Abadi Hospital. This is a descriptive study, dealing with 57526 cases of live birth out of 59477 medical files in Akbar Abadi Hospital from 2004 to 2008. All the collected data were recorded in speci...

O ral clefts are the most common congenital malformations worldwide. Cleft palate can be non-syndromic (MIM 119540) or it can appear as a part of a syndrome or recurrence pattern. Non-syndromic cleft palate and non-syndromic cleft lip with or without cleft palate (CL/P) are considered to be separate entities, on the basis of different embryonic timing and epidemiology. However, in some syndrome...

This study was done to determine the prevalence of dental anomalies and facial profile abnormality and its association with the non-syndromic cleft lip and palate (CLP) as compared to the non-cleft children. A comparative cross sectional study was conducted where the case group consist of 98 non-syndromic CLP children-unilateral (UCLP) and bilateral (BCLP) who attended the Combined Clinic at Ko...

Orofacial clefts are one of the commonest birth defects, and may be associated with other congenital anomalies. The majority of these orofacial clefts are nonsyndromic . A significant percentage of these clefts both syndromic and non-syndromic may have associated anomalies. Apart from reviewing other studies, this article also analyses a study of associated anomalies from a tertiary cleft centr...

Cleft lip with/without palate (CL/P) is is perhaps the most common major birth defect and occurs in approximately 0.4-2 per 1000 liveborn infants in most populations depending on the geographic origin and ethnic background worldwide (1,2) In man, about 30% of cases are syndromic and in the rest (70%) of them, CL/P occurs as an isolated, sporadic defect where the clefts are without other anomali...

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all congenital malformations and has a multifactorial etiology. Findings in mice suggest that the v-ski sarcoma viral oncogene homolog (SKI) gene is a candidate gene for orofacial clefting. In humans, a significant association between rs2843159 within SKI and NSCL/P has been reported in patients from the ...