BACKGROUND AND PURPOSE T2 hypointensity in the basal ganglia of patients with MS has been associated with clinical progression and cognitive decline. Our objectives were the following: 1) to compare signal in T2WI, R2 (ie, 1/T2), and R2* (ie, 1/T2*) relaxation rates and quantitative susceptibility mapping; and 2) to investigate the associations among MR imaging, clinical scores, and cognitive m...

Purpose: Quantitative susceptibility mapping (QSM) is a valuable new approach for subcortical brain iron mapping [1,2]. However, acquisition times are typically on the order of 5-10 minutes, which is acceptable in dedicated studies but limits wider use in the clinic for standard brain exams due to the considerable time penalty. The aim is to develop and test an extremely rapid means (under 10 s...

BACKGROUND AND PURPOSE A hyperintense rim on susceptibility in chronic MS lesions is consistent with iron deposition, and the purpose of this study was to quantify iron-related myelin damage within these lesions as compared with those without rim. MATERIALS AND METHODS Forty-six patients had 2 longitudinal quantitative susceptibility mapping with automatic zero reference scans with a mean int...

BACKGROUND AND PURPOSE Quantitative susceptibility mapping has been used to characterize iron and myelin content in the deep gray matter of patients with multiple sclerosis. Our aim was to characterize the susceptibility mapping of cortical lesions in patients with MS and compare it with neuropathologic observations. MATERIALS AND METHODS The pattern of microglial activation was studied in po...

BACKGROUND AND PURPOSE Quantitative susceptibility mapping has been shown to assess iron content in cerebral cavernous malformations. In this study, our aim was to correlate lesional iron deposition assessed by quantitative susceptibility mapping with clinical and disease features in patients with cerebral cavernous malformations. MATERIALS AND METHODS Patients underwent routine clinical scan...

The genetics of asthma and atopy is complex, but can be approached by studies of both candidate genes and mapping of susceptibility loci. Genetic factors conferring susceptibility to disease may vary among ethnic groups. We present our experience with some candidate gene studies for asthma and atopy and susceptibility locus mapping for linkage to chromosome 5q.