Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched controls were recruited for this study. Serum total antioxidant ...

Thimerosal generates ethylmercury in aqueous solution and is widely used as preservative. We have investigated the toxicology of Thimerosal in normal human astrocytes, paying particular attention to mitochondrial function and the generation of specific oxidants. We find that ethylmercury not only inhibits mitochondrial respiration leading to a drop in the steady state membrane potential, but al...

Objectives: The present study is aimed at investigating the involvement of oxidative stress in ischemic heart disease (IHD) of patients in tertiary care hospital in Kolkata. Methods: Serum parameters of myocardial injury, oxidative stress biomarkers and antioxidant enzymes were measured. These data were supported by the data of electrocardiography and echocardiography. Results: The current stud...

The polymer supported hypochlorite ion is a facile selective oxidizing agent for the oxidation of various alcohols to aldehydes and ketones. Similarly is successfully oxidizes various Hantzsch type 1,4- dihydropyridines to corresponding pyridines.

Organohypervalent iodine reagents have attracted significant recent interest as versatile and environmentally benign oxidants with numerous applications in organic synthesis. This Perspective summarizes synthetic applications of hypervalent iodine(V) reagents: 2-iodoxybenzoic acid (IBX), Dess-Martin periodinane (DMP), pseudocyclic iodylarenes, and their recyclable polymer-supported analogues. R...

Serotonin (5-HT) stimulates mitogenesis in rat renal mesangial cells through a G protein-coupled 5-HT(2A) receptor. We tested the hypothesis that oxidants might be involved in the signal transduction pathway linking the receptor to extracellular signal-regulated protein kinase (ERK). 5-HT rapidly increased the activity and phosphorylation of ERK. These effects were blocked by the 5-HT(2A) recep...

unsubstituted phthalocyanines of co, fe and mn supported on zinc oxide nanoparticles were prepared and were well characterized with x-ray diffraction (xrd) and scanning electron microscopy (sem). the oxidation of alcohols with tert-butylhydroperoxide (tbhp), in the presence of metallophthalocyanines (mpc) supported on zinc oxide nanoparticles was investigated. these mpc/zno nanocomposites were ...

BACKGROUND Neural stem and progenitor cells of the Enteric Nervous System (ENS) are regarded as a novel cell source for applications in regenerative medicine. However, improvements to the current ENS cell culture protocols will be necessary to generate clinically useful cell numbers under defined culture conditions. Beneficial effects of physiologically low oxygen concentrations and/or the addi...

Iron (III) meso-tetrakis(p-sulfonatophenyl)-β-octabromoporphyrin supported on Amberlite IRA- 400 [Fe(Br8 TPPS)-Ad-400] is a robust and efficient catalyst for oxidation of alkenes and alcohols at room temperature. The catalyst exhibits a high activity and stability in hydrocarbon oxidation by H2 O2 . The method was useful in the oxidation of various primary, secondary-aliphatic, alicyclic and ar...