In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr). In this work, we studied the metabolism of glioma tumours by in vitro proton magnetic resonance spectroscopy (1H-MRS)....

the median overall survival in glioblastoma multiforme is usually less than one year. long-term survival is rare and is seen in only 3%-6% of gbm patients. the present study reports the characteristics and treatment outcomes of six cases of glioblastoma multiforme with long-term survival. a literature review is also presented. between 1990 and 2008, 217 glioblastoma multiforme patients have bee...

PURPOSE There is growing interest in developing cellular immune therapies for glioblastoma multiforme, but little is known about tumor-specific T-cell responses. A glioblastoma multiforme-specific T-cell assay was developed using monocyte-derived dendritic cells to present tumor antigens from the established glioblastoma multiforme cell line U118. EXPERIMENTAL DESIGN Peripheral blood mononucl...

Investigating the molecular composition of small extracellular vesicles (sEVs) for tumor diagnostic purposes is becoming increasingly popular, especially diseases which diagnosis challenging, such as central nervous system (CNS) malignancies. Thorough examination content sEVs by Raman spectroscopy a promising but hitherto barely explored approach these types. We attempt to reveal potential role...

background: this paper proposes a new emotional stress assessment system using multi-modal bio-signals. electroencephalogram (eeg) is the reflection of brain activity and is widely used in clinical diagnosis and biomedical research. methods: we design an efficient acquisition protocol to acquire the eeg signals in five channels (fp1, fp2, t3, t4 and pz) and peripheral signals such as blood volu...

estimation of the conceptual costs in construction projects can be regarded as an important issue in feasibility studies. this estimation has a major impact on the success of construction projects. indeed, this estimation supports the required information that can be employed in cost management and budgeting of these projects. the purpose of this paper is to introduce an intelligent model to im...

finding repetitive subsequences in genome is a challengeable problem in bioinformatics research area. a lot of approaches have been proposed to solve the problem, which could be divided to library base and de novo methods. the library base methods use predetermined repetitive genome’s subsequences, where library-less methods attempt to discover repetitive subsequences by analytical approaches. ...

support vector regression (svr) solves regression problems based on the concept of support vector machine (svm). in this paper, a new model of svr with probabilistic constraints is proposed that any of output data and bias are considered the random variables with uniform probability functions. using the new proposed method, the optimal hyperplane regression can be obtained by solving a quadrati...

objective(s): glioblastoma multiforme (gbm) is one of the most lethal forms of human cancer and temozolomide (tmz) is currently part of the standard treatment for this disease. combination therapy using natural substances can enhance the anti-cancer activity of tmz. the purpose of this study was to evaluate the effect of tmz in combination with thymoquinone (tq) on human gbm cell line (u87mg). ...