The relationship between vascular generation of superoxide anion and spontaneous tone observed in the isolated aorta was studied in hypertensive rats infused with angiotensin II. Aortic rings from hypertensive, but not from sham-operated rats, demonstrated oscillatory spontaneous tone that represented 52+/-5.6% of the maximal contraction to KCl. Spontaneous tone was prevented by calcium-free bu...

Using a highly sensitive and specific chemiluminescence (CL) method, we detected the release of superoxide anion (O2-.) from human polymorphonuclear leukocytes (PMNLs) stimulated by rubella viral antigen-antibody complex (VAAC) adsorbed on latex particles. The amount of superoxide anion produced by PMNLs was proportional to the amount of VAAC. Neither rubella virus alone nor antibody alone, ads...

Superoxide and other oxygen radicals produced by activated polymorphonuclear leukocytes (PMN) may be important causes of tissue damage in a number ofinflammatory conditions. Therefore, a drug which suppresses PMN responses in vivo is potentially important. In vitro, pentoxifylline (PTOX) inhibits superoxide anion production when PMN are stimulated with an activated complement component (C5a Des...

the present study was designed to explore the flavonoid contents and the radical scavenging activities of 50% ethanol extracts of leaves, stems, rachis and roots of dryopteris erythrosora. the total flavonoid contents in various parts were determined as: stems > roots > rachis > leaves. all extracts from different parts of d. erythrosora showed strong bioactivities. the dpph free radical scaven...

the present work is carried out to study the antioxidant potential of ethanolic extract of alstonia scholaris linn. ( apocynaceae ) using various in vitro tests including 1,1-diphenyl-2-picryl-hydrazil (dpph . ) free radical scavenging, metal ion chelating, hydrogen peroxide scavenging, superoxide anion radical scavenging, and ferric thiocyanate reducing ability.   ethanolic extract of alstonia...

It is currently accepted that superoxide anion (O2•-) is an important mediator in pain and inflammation. The role of superoxide anion in pain and inflammation has been mainly determined indirectly by modulating its production and inactivation. Direct evidence using potassium superoxide (KO2), a superoxide anion donor, demonstrated that it induced thermal hyperalgesia, as assessed by the Hargrea...

Only very limited information regarding the protective effects of the superoxide anion scavenger on chronic intermittent hypoxia-induced cardiac apoptosis is available. The purpose of this study is to evaluate the effects of the superoxide anion scavenger on cardiac apoptotic and prosurvival pathways in rats with sleep apnea. Forty-two Sprague-Dawley rats were divided into three groups, rats wi...