نتایج جستجو برای: superinfection
تعداد نتایج: 1511 فیلتر نتایج به سال:
The rapid evolution of HIV drug resistance is a major cause of AIDS treatment failure. Superinfection, the infection of an already infected cell by additional virions, can be a major factor contributing to the evolution of drug resistance. However, the pattern and consequences of superinfection in HIV populations are far from fully understood. In this paper we study the implications of the fact...
UNLABELLED Superinfection exclusion is a widespread phenomenon that prevents secondary infections by closely related viruses. The vaccinia virus A56 and K2 proteins in the cell membrane can prevent superinfection by interacting with the entry-fusion complex of subsequent viruses. Here, we described another form of exclusion that is established earlier in infection and does not require the A56 o...
BACKGROUND It has been suggested that superinfection of HIV positive individuals with heterologous HIV strains could lead to faster progression to AIDS, generating concern over the risks of exposure to new infections in those already infected. METHODS A mathematical model of the within-host dynamics of two sequential infections with strains of HIV describing activation and infection of immune...
HIV superinfection, which occurs when a previously infected individual acquires a new distinct HIV strain, has been described in a number of populations. Previous methods to detect superinfection have involved a combination of labor-intensive assays with various rates of success. We designed and tested a next-generation sequencing (NGS) protocol to identify HIV superinfection by targeting two r...
Latent viruses generally defend their host cell against superinfection by nonlatent virulent mutants that could destroy the host cell. Superinfection inhibition thus seems to be a prerequisite for the maintenance of viral latency. Yet viral latency can break down when resistance to superinfection inhibition, known as ultravirulence, occurs. To understand the evolution of viral latency, we have ...
Purpose of the research: study clinical and epidemiological characteristics Acute Hepatitis B with Delta agent (AHD) in Kyrgyzstan. Materials Methods: State Reporting Forms No. 1 “Report on infectious parasitic disease” for 1999-2018 were reviewed. The data 115 patients AHD analyzed, who received inpatient treatment 2000-2018, Bishkek. was processed by Epi Info 3.8.1. Results. In Kyrgyzstan, on...
BACKGROUND Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed...
Background: Cutaneous leishmaniasis is a common parasitic disease in Isfahan province. A common complication of cutaneous leishmaniasis is bacterial superinfection, which may intensify the disease and produce scarring. Objective: The aim of this study was to determine the bacterial species isolated from infected lesions of cutaneous leishmaniasis. Patients and Methods: Two hundred out of ...
BACKGROUND Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown. METHODS A novel next-generation ultra-deep sequencing technique was utilized to determine the rate of HIV superinfection in a heterosexual population by examining two regions o...
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