Abbreviations: BBB: Blood Brain Barrier; Ca: Calcium; CT: Computed Tomography; EM: Electro-Magnetic; EMA: European Medicines Agency; FDA: (U.S.) Food And Drug Administration; Fmri: Functional Magnetic Resonance Imaging; Gd: Gadolinium; GI: Gastro-Intestinal; IV: Intra-Venous; Mn: Manganese; MEMRI: Manganese-Enhanced MRI; Mn-DPDP: Chelated Manganese Nanoparticles; MRA: Magnetic Resonance Angiogr...

Introduction: Iron plays an important role in physiological processes as a trace element. Today, iron oxide nanoparticles have attracted extensive attention due to their super paramagnetic properties and a variety of potential applications in many fields. The main objective of this study was to evaluate in vitro and in vivo toxic effects of the iron oxide nanoparticles on L929 cell line, kidney...

Abstract The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were synthesized and encapsulated simultaneously with Gemcitabine (Gem) in PLGA±PEG copolymers via W/O/W double emulsification me...

background: to date, several imaging techniques to track stem cells are used such as positron emission tomography (pet), single photon emission computed tomography (spect), bioluminescence imaging (bli), fluorescence imaging, ct scan and magnetic resonance imaging (mri). although, overall sensitivity of mri compared to spect and bioluminescence techniques are lower, but due to high spatial reso...

Thermally modulated photoacoustic imaging (TMPI) is reported here for contrast enhancement when using nanoparticles as contrast agents. Exploiting the excellent sensitivity of the photoacoustic (PA) process on temperature and the highly selective heating capability of nanoparticles under electromagnetic field, the PA signals stemming from the nanoparticles labeled region can be efficiently modu...

Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe₃O₄·DA-BSA/HA in water. Fe₃O₄·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug pacli...

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA ± PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were simultaneously synthesized and encapsulated with Gemcitabine (Gem) in PLGA ± PEG copolymers via W/O/W double emulsification method. Optimum size and ...

Nanocomposites of metal oxides with graphene oxide and other carbon materials have shown superior catalytic activities in many important chemical reactions. A systematic investigation the effect Fe, Co, Ni, Cu, and Zn, on sulfonated (GO) is detailed in present paper. The nanocomposites GO were prepared under carefully chosen conditions so that content nanocomposites remains similar. used ...

Metal clusters, composed of a few atoms at the core, exhibit unique properties and have potential applications. Although atomically precise clusters of noble metals have been synthesized, analogous systems of reactive metals, such as iron, have not been realized in solution due to high reactivity. Here we report the synthesis and characterization of novel iron clusters in the hemoglobin matrix ...