In this commentary, Qun Zheng and Michael L. Nonet examine Edwards et al.’s article in which they provide evidence for a domain in invertebrate neurons similar to the vertebrate axonal initial segment that serves to restrict certain organelles from entering the axonal compartment. In their article published in this month’s GENETICS, Edwards et al. (2013) implicate the UNC-16/JIP3/SYD as a criti...

Neuronal development, function and repair critically depend on axonal transport of vesicles and protein complexes, which is mediated in part by the molecular motor kinesin-1. Adaptor proteins recruit kinesin-1 to vesicles via direct association with kinesin heavy chain (KHC), the force-generating component, or via the accessory light chain (KLC). Binding of adaptors to the motor is believed to ...

PURPOSE On 1 May 1996, Ontario, Canada amended the Liquor Licence Act to extend the hours of alcohol sales and service in licensed establishments from 1 to 2 a.m. The purpose of this study was to evaluate the road safety impact of extended drinking hours in Ontario. METHOD A quasi-experimental design using interrupted time series with a nonequivalent no-intervention control group was used to ...

. Sir, Will you please find .1 little space for my proposal 111 your valuable paper and oblige. It is rather curious that the medical department should have no holiday unlike other departments, and it is sometimes a matter which causes great inconvenience to its employs. Some years back the work of the Indian dispensaries was light as most of the people were used to the eastern methods of treat...

Many US states and Canadian provinces have recently lifted bans on off-premise retail liquor sales on Sundays, yet there is no evidence on how such provisions affect drinking. We investigate this issue using unique information on day-specific alcohol consumption from Canada’s National Population Health Surveys (1994-1999) and variation across provinces in the presence of a Sunday sales restrict...

Sunday shop opening is deregulated to the municipal level in the Netherlands. Despite positive effects on economic growth and employment, many municipalities restrict Sunday shop opening. Based on 2003 data we show that diverse local characteristics, like the size of municipalities and religious and political affiliation, play a major role in decisions about Sunday shop opening. The evidence is...

A broadly conserved membrane-associated protein required for the functional interaction of kinesin-I with axonal cargo was identified. Mutations in sunday driver (syd) and the axonal transport motor kinesin-I cause similar phenotypes in Drosophila, including aberrant accumulations of axonal cargoes. GFP-tagged mammalian SYD localizes to tubulovesicular structures that costain for kinesin-I and ...