Aromatic amines are oxidized in animal tissues to oand p-aminophenols, which are rapidly conjugated to give either sulphates or glucosiduronates. Some of the carcinogenic aromatic amines appear to produce their biological effects after conversion into o-aminophenols. 2-Naphthylamine, for example, which produces bladder cancer, is oxidized to 2-amino-6-naphthol and 2-amino-inaphthol by liver sli...

Partial molar volumes of copper sulphate and zinc sulphate have been determined in water and binary aqueous mixtures of propylene glycol (2,4,6 and 8% by weight of propylene glycol) at 303.15 K with the help of density measurements. Effect of temperature on the partial molar volumes was also analysed for these salts in water and binary aqueous mixtures of propylene glycol. Results obtained have...

Nanotechnology is an emerging science offering promising models of decontamination. The present experimental design is to synthesize novel nanoparticles of Iron and Nickel oxides to be used as catalysts for in situ removal of different pollutants discharged from various industries. Particle size of synthesized iron and nickel oxides nanoparticles was characteristic of ~28-36 nm and ~48-56, resp...

Indican is derived from indol, and unlike the other ethereal sulphates which are derived in part from metabolism, originates practically wholly from putrefactive processes. It, alone, therefore, and not the total ethereal sulphates, has been taken as an index of such putrefaction (1). The determination of indican depends upon its decomposition and oxidation of the liberated indoxyl into indigo-...

1. The 3-sulphates of cholic, chenodeoxycholic and deoxycholic acids were prepared as crystalline disodium salts. 2. The method described shows that it is possible to prepare specific sulphate esters of polyhydroxy bile acids and to remove protecting acyl groups without removing the sulphate. 3. A study of bile acid sulphate solvolysis showed that none of the usual methods give the original bil...

In a preliminary study, the 24-hour urinary excretion of corticosteroid sulphates and free cortisol have been measured in a group of patients with breast cancer and compared with the excretion of the same compounds in a group of normal women of similar age. Excretion of corticosteroid sulphates in the breast cancer group was found to be markedly raised. In a small number of patients with locali...

5. The rate of synthesis of 2-naphthyl sulphamate by rat-liver preparations is increased by about 400% by 17-oxo steroids in concentrations of approximately 10-5M. 6. The rate ofsynthesis ofsulphamate byguineapig preparations is not increased by 17-oxo steroids. 7. It is suggested that the mechanism of this activation involves the formation of steroid 17-enol sulphates and that these enol sulph...