The presence of methemoglobin, more rarely sulfhemoglobin, in the blood of patients treated with sulfanilamide has been reported by many investigators (1 a-f). Evelyn and Malloy (2), using their photoelectric colorimeter, found both these pigments but felt they were not responsible for the " cyanosis." Wendel (3), using his visual spectroscopic method (4), found methemoglobin and (occasionally)...

BACKGROUND Hydrogen sulfide (H2S) exhibits both physiological and toxicological roles in the biological systems. Acute exposure to high levels of H2S is life threatening while long-term exposure to ambient levels of H2S elicits human health effects. OBJECTIVE To study the harmful effects of long-term exposure to low levels of H2S on human blood cells. METHODS 110 adult workers from Iran who...

We have stated in a preliminary report that the cyanosis observed in individuals treated with sulfanilamide is due to methemoglobin, and rarely, to sulfhemoglobin (1). We recognized at the time that attempts had been made to explain the presence of cyanosis on a different basis.. Marshall and Walzl (2) maintained that a black pigment derived from sulfanilamide, and present in the blood, was the...

The principal function of the protein hemoglobin contained in red blood cells is transport of oxygen in inspired air from lungs to tissue cells. Although normally present in only trace amounts, there are three species of hemoglobin that cannot transport oxygen. The three species, collectively called the dyshemoglobins because of their functional redundancy, are: carboxyhemoglobin, sulfhemoglobi...

There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The results of these experiments, in turn, may be incorporated in the design of differential protocols for...