280. Association between acessory gene regulator II expression and mortality among critically ill patients receiving vancomycin for hospitalacquired methicillin-resistant Staphylococcus aureus bacteremia Regis Rosa, MD, MS; Eduardo Turra; Denise Machado, PhD; Angelica Cechinel; Rodrigo Dos Santos, MD, PhD; Luciano Goldani, PhD, MD; PPG Em Ciências Médicas, Ufrgs Faculty of Medicine, Porto Alegr...

1PhD, Medical Microbiology Laboratory, Universidade de Caxias do Sul, RS, Brazil 2MS; Medical Microbiology Laboratory, Universidade de Caxias do Sul, RS, Brazil 3Pharmacist; Medical Microbiology Laboratory, Universidade de Caxias do Sul, RS, Brazil 4PhD,Instituto de Biotecnologia, Universidade de Caxias do Sul, RS, Brazil 5PhD, Hospital de Clínicas de Porto Alegre, RS, Brazil 6PhD, Instituto de...

In 200 sulfonamide-resistant Portuguese Salmonella isolates, 152 sul1, 74 sul2, and 14 sul3 genes were detected. Class 1 integrons were always associated with sul genes, including sul3 alone in some isolates. The sul3 gene has been identified in isolates from different sources and serotypes, which also carried a class 1 integron with aadA and dfrA gene cassettes.

AIMS This study was carried to reveal the genetic mechanisms of trimethoprim/sulfamethoxazole (SXT) resistance. METHODS Among 300 clinical Stenotrophomonas maltophilia isolates from China, resistance determinants such as sul and dfrA genes, integrons and transposase were examined using PCR, DNA sequencing and thermal asymmetric interlaced PCR (TAIL-PCR). Data were analyzed using SPSS 20.0. ...

The natural indoles 3,3 -diindolylmethane (DIM), ascorbigen (ASG), indole-3-carbinol (I3C), and indolo[3,2-b]carbazole (ICZ), as well as the natural isothiocyanates sulforaphane (SUL), benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC), all possess cancer chemopreventive properties. It is now shown that DIM, ICZ, SUL, and BITC can each stimulate apoptosis in human colon adenocarc...

The natural indoles 3,3'-diindolylmethane (DIM), ascorbigen (ASG), indole-3-carbinol (I3C), and indolo[3,2-b]carbazole (ICZ), as well as the natural isothiocyanates sulforaphane (SUL), benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC), all possess cancer chemopreventive properties. It is now shown that DIM, ICZ, SUL, and BITC can each stimulate apoptosis in human colon adenocarc...

1Laboratory of Analysis and Toxicological Research, Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul Toxicology Laboratory, 2National Agricultural Laboratory of Rio Grande do Sul, LANAGRO/RS , 3Toxicology Information Center of Rio Grande do Sul, State Foundation of Production and Research in Health, 4Department of Botany, Federal University of Rio Grande do S...

BACKGROUND Leptospirosis is an epidemic-prone neglected disease that affects humans and animals, mostly in vulnerable populations. The One Health approach is a recommended strategy to identify drivers of the disease and plan for its prevention and control. In that context, the aim of this study was to analyze the distribution of human cases of leptospirosis in the State of Rio Grande do Sul, Br...

The mechanisms of antimicrobial resistance were characterized in 90 Salmonella enterica isolates either resistant or with intermediate resistance to amoxicillin/clavulanate (AMC(R/I)) or resistant to third-generation cephalosporins (C3G(R)). These isolates were recovered in three Spanish hospitals during 2007-2009. The C3G(R) phenotype was expressed by three isolates that carried the following ...

Klebsiella pneumoniae is one of the most important opportunistic enteric bacteria and is a major cause of pneumonia and urinary tract infection. Serotype capsules of K1 and K2 can cause intense diseases. Acquisition of plasmid that codes the production of ESBLs confers on K. pneumoniae resistance to number of broad spectrum antibiotics posing a global public health problem. Integron is one of t...