نتایج جستجو برای: suicide gene
تعداد نتایج: 1164769 فیلتر نتایج به سال:
Background: The herpes simplex virus (HSV) UL41 gene product, virion host shutoff (Vhs) protein, mediates the rapid degradation of both viral and cellular mRNA. This ability suggests that Vhs protein can be used as a suicide gene in cancer gene therapy applications. The recent reports have shown that the degradation of cellular mRNA during herpes simplex infection is selective. RNA containing A...
Long-term clinical remissions of leukemia, after allogeneic hematopoietic stem cell transplantation, depend on alloreactive memory T cells able to self-renew and differentiate into antileukemia effectors. This is counterbalanced by detrimental graft-versus-host disease (GVHD). Induction of a selective suicide in donor T cells is a current gene therapy approach to abrogate GVHD. Unfortunately, g...
Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial gene, which allows the conversion of a non-toxic compound into a lethal drug. Although suicide gene therapy has been successfully used in a large number of in vitro and in vivo studies, its application to cancer patients has not reached the desirable clinical significance. However, recent reports on pre...
Suicide is a complex and multifaceted public health issue that has been intensively studied to identify its contributing factors. Serotonin, neurotransmitter essential for affective regulation mood control, linked suicidal propensity. Understanding the relative contribution of serotonin’s genetic versus non-genetic influences development effective preventive measures, given etiology suicide inv...
BACKGROUND To investigate the selective killing efficacy of the double suicide genes driven by KDR promoter. MATERIALS AND METHODS A double suicide gene system with the KDR promoter, pcDNA3-KDRp-CDglyTK, was constructed and transfected into lung cancer cell lines L9981 and NL9980, and human hepatocellular carcinoma cell line HepG2. The efficiency and specificity of the double suicide gene sys...
BACKGROUND Serotonin (5-HT) is an important neurotransmitter with wide-ranging functions. Its disfunction in the central nervous system seems to play an important role in many psychiatric disorders and suicidal behavior. The objective of this study was to examine the association between polymorphisms in different serotonin receptor genes (HTR): HTR1A (polymorphism -1019C>G), HTR1B (polymorphism...
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